Traumatic spinal cord injury (SCI) has devastating consequences for the physical, social and
vocational well-being of patients. The demographic of SCIs is shifting such that an …

Spinal cord injury (SCI) is a devastating neurological disorder that affects thousands of
individuals each year. Over the past decades an enormous progress has been made in our …

Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

Background: Animal spinal cord injury (SCI) models have proved invaluable in better
understanding the mechanisms involved in traumatic SCI and evaluating the effectiveness of …

Reactive astrocytes are prominent in the cellular response to spinal cord injury (SCI), but
their roles are not well understood. We used a transgenic mouse model to study the …

Injury reproducibility is an important characteristic of experimental models of spinal cord
injuries (SCI) because it limits the variability in locomotor and anatomical outcome …

Signaling mechanisms that regulate astrocyte reactivity and scar formation after spinal cord
injury (SCI) are not well defined. We used the Cre recombinase (Cre)-loxP system under …

This review summarizes the current understanding of spinal cord injury pathophysiology and
discusses important emerging regenerative approaches that have been translated into …

Axonal degeneration is a common pathological feature in many acute and chronic
neurological diseases such as spinal cord injury (SCI). SARM1 (sterile alpha and TIR motif …

Placental tissue draws great interest as a source of cells for regenerative medicine because
of the phenotypic plasticity of many of the cell types isolated from this tissue. Furthermore …