Cell-type-specific adaptions in striatal medium-sized spiny neurons and their roles in behavioral responses to drugs of abuse
MC Allichon, V Ortiz, P Pousinha… - Frontiers in synaptic …, 2021 - frontiersin.org
Drug addiction is defined as a compulsive pattern of drug-seeking-and taking-behavior, with
recurrent episodes of abstinence and relapse, and a loss of control despite negative …
recurrent episodes of abstinence and relapse, and a loss of control despite negative …
Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior
The idea that interconnected neuronal ensembles code for specific behaviors has been
around for decades; however, recent technical improvements allow studying these networks …
around for decades; however, recent technical improvements allow studying these networks …
Cocaine-regulated microRNA miR-124 controls poly (ADP-ribose) polymerase-1 expression in neuronal cells
MiR-124 is a highly expressed miRNA in the brain and regulates genes involved in neuronal
function. We report that miR-124 post-transcriptionally regulates PARP-1. We have identified …
function. We report that miR-124 post-transcriptionally regulates PARP-1. We have identified …
Astrocytes in addictive disorders
A Kruyer, MD Scofield - Astrocytes in Psychiatric Disorders, 2021 - Springer
Astroglia are key regulators of synaptic function, playing central roles in homeostatic ion
buffering, energy dynamics, transmitter uptake, maintenance of neurotransmitter pools, and …
buffering, energy dynamics, transmitter uptake, maintenance of neurotransmitter pools, and …
BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors
EM Anderson, AM Wissman… - Proceedings of the …, 2017 - National Acad Sciences
Chronic cocaine use is associated with prominent morphological changes in nucleus
accumbens shell (NACsh) neurons, including increases in dendritic spine density along with …
accumbens shell (NACsh) neurons, including increases in dendritic spine density along with …
Ubiquitin-proteasomal regulation of chromatin remodeler INO80 in the nucleus accumbens mediates persistent cocaine craving
Neuroadaptations in the nucleus accumbens (NAc) underlie cue-induced cocaine craving
that intensifies (“incubates”) during abstinence and is believed to contribute to persistent …
that intensifies (“incubates”) during abstinence and is believed to contribute to persistent …
It is a complex issue: emerging connections between epigenetic regulators in drug addiction
EM Anderson, RD Penrod, SM Barry… - European Journal of …, 2019 - Wiley Online Library
Drug use leads to addiction in some individuals, but the underlying brain mechanisms that
control the transition from casual drug use to an intractable substance use disorder (SUD) …
control the transition from casual drug use to an intractable substance use disorder (SUD) …
Poly (ADP-Ribose) polymerase-1 (PARP-1) induction by cocaine is post-transcriptionally regulated by miR-125b
Cocaine exposure alters gene expression in the brain via methylation and acetylation of
histones along with methylation of DNA. Recently, poly (ADP-ribose) polymerase-1 (PARP …
histones along with methylation of DNA. Recently, poly (ADP-ribose) polymerase-1 (PARP …
E3 ubiquitin-protein ligase SMURF1 in the nucleus accumbens mediates cocaine seeking
CT Werner, R Viswanathan, JA Martin, PH Gobira… - Biological …, 2018 - Elsevier
Background Substance use disorder is a neurobiological disease characterized by episodes
of relapse despite periods of withdrawal. It is thought that neuroadaptations in discrete brain …
of relapse despite periods of withdrawal. It is thought that neuroadaptations in discrete brain …
Challenges on cyclic nucleotide phosphodiesterases imaging with positron emission tomography: novel radioligands and (pre-) clinical insights since 2016
S Schröder, M Scheunemann, B Wenzel… - International Journal of …, 2021 - mdpi.com
Cyclic nucleotide phosphodiesterases (PDEs) represent one of the key targets in the
research field of intracellular signaling related to the second messenger molecules cyclic …
research field of intracellular signaling related to the second messenger molecules cyclic …