Drug addiction is defined as a compulsive pattern of drug-seeking-and taking-behavior, with
recurrent episodes of abstinence and relapse, and a loss of control despite negative …

The idea that interconnected neuronal ensembles code for specific behaviors has been
around for decades; however, recent technical improvements allow studying these networks …

MiR-124 is a highly expressed miRNA in the brain and regulates genes involved in neuronal
function. We report that miR-124 post-transcriptionally regulates PARP-1. We have identified …

Astroglia are key regulators of synaptic function, playing central roles in homeostatic ion
buffering, energy dynamics, transmitter uptake, maintenance of neurotransmitter pools, and …

Chronic cocaine use is associated with prominent morphological changes in nucleus
accumbens shell (NACsh) neurons, including increases in dendritic spine density along with …

Neuroadaptations in the nucleus accumbens (NAc) underlie cue-induced cocaine craving
that intensifies (“incubates”) during abstinence and is believed to contribute to persistent …

Drug use leads to addiction in some individuals, but the underlying brain mechanisms that
control the transition from casual drug use to an intractable substance use disorder (SUD) …

Cocaine exposure alters gene expression in the brain via methylation and acetylation of
histones along with methylation of DNA. Recently, poly (ADP-ribose) polymerase-1 (PARP …

Background Substance use disorder is a neurobiological disease characterized by episodes
of relapse despite periods of withdrawal. It is thought that neuroadaptations in discrete brain …

Cyclic nucleotide phosphodiesterases (PDEs) represent one of the key targets in the
research field of intracellular signaling related to the second messenger molecules cyclic …