Kisspeptin (a product of the Kiss1 gene) and its receptor (GPR54 or Kiss1r) have emerged
as key players in the regulation of reproduction. Mutations in humans or genetically targeted …

Abstract Melatonin (N-acetyl-5-methoxytryptamine) has revealed itself as an ubiquitously
distributed and functionally diverse molecule. The mechanisms that control its synthesis …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Kisspeptin signaling via the kisspeptin receptor G‐protein‐coupled receptor‐54 plays a
fundamental role in the onset of puberty and the regulation of mammalian reproduction. In …

Kisspeptin and G protein-coupled receptor 54 (GPR54) are now acknowledged to play
essential roles in the neural regulation of fertility. Using a transgenic Gpr54 LacZ knock-in …

Kisspeptin‐GPR54 signalling is essential for normal reproductive functioning. However, the
distribution of kisspeptin neuronal cell bodies and their projections is not well established …

Signaling between kisspeptin and its receptor, G-protein-coupled receptor 54 (Gpr54), is
now recognized as being essential for normal fertility. However, the key cellular location of …

In late 2003, a major breakthrough in our understanding of the mechanisms that govern
reproduction occurred with the identification of the reproductive roles of kisspeptins …

Kisspeptins are new actors in the neuroendocrine regulation of reproduction. In vertebrates,
the number of kiss genes varies from none to three. Zebrafish have two kiss genes, kiss1 …

Leptin is an adipocyte-derived hormone involved in a myriad of physiological process,
including the control of energy balance and several neuroendocrine axes. Leptin-deficient …