From the laboratory perspective, effective management of patients with chronic myeloid
leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential …

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm and was the first
neoplastic disease associated with a well-defined genotypic anomaly―the presence of the …

Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome
(Ph) which results from a reciprocal translocation between chromosomes 9 and 22 [t (9; 22] …

Chronic myeloid leukemia (CML) is defined by the presence of Philadelphia chromosome
resulting from a reciprocal translocation between chromosomes 9 and 22 [t9; 22] that gives …

Abstract The oncogenic protein Bcr-Abl has two major isoforms, p190Bcr-Abl and p210Bcr-
Abl. While p210Bcr-Abl is the hallmark of chronic myeloid leukemia (CML), p190Bcr-Abl …

Purpose of review In this review, we emphasize up-to-date practical cytogenetic and
molecular aspects of chronic myeloid leukemia (CML) and summarize current knowledge on …

Fusion genes are hallmarks of various cancer types and important determinants for
diagnosis, prognosis and treatment. Fusion gene partner choice and breakpoint-position …

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm initiated by the presence
of the fusion gene BCR:: ABL1. The development of tyrosine kinase inhibitors (TKIs) highly …

Chronic myeloid leukemia (CML) is characterized by the presence of the BCR-ABL1 fusion
gene. In more than 95% of CML patients, the typical BCR-ABL1 transcript subtypes are …

Chronic myeloproliferative neoplasms (MPNs) are hematopoietic stem cell neoplasms with
driver events including the BCR-ABL1 translocation leading to a diagnosis of chronic …