Zebrafish as an emerging model for studying complex brain disorders

AV Kalueff, AM Stewart, R Gerlai - Trends in pharmacological sciences, 2014 - cell.com
The zebrafish (Danio rerio) is rapidly becoming a popular model organism in
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …

The developing utility of zebrafish models of neurological and neuropsychiatric disorders: A critical review

BD Fontana, NJ Mezzomo, AV Kalueff… - Experimental …, 2018 - Elsevier
Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …

Zebrafish: an emerging real-time model system to study Alzheimer's disease and neurospecific drug discovery

S Saleem, RR Kannan - Cell death discovery, 2018 - nature.com
Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational
research on human neurological disorders. In this review, we appraise the high degree of …

Comparative analyses of zebrafish anxiety-like behavior using conflict-based novelty tests

EV Kysil, DA Meshalkina, EE Frick, DJ Echevarria… - Zebrafish, 2017 - liebertpub.com
Modeling of stress and anxiety in adult zebrafish (Danio rerio) is increasingly utilized in
neuroscience research and central nervous system (CNS) drug discovery. Representing the …

Zebrafish models in neuropsychopharmacology and CNS drug discovery

KM Khan, AD Collier, DA Meshalkina… - British journal of …, 2017 - Wiley Online Library
Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …

Zebrafish as potential model for developmental neurotoxicity testing: a mini review

C De Esch, R Slieker, A Wolterbeek… - Neurotoxicology and …, 2012 - Elsevier
The zebrafish is a powerful toxicity model; biochemical assays can be combined with
observations at a structural and functional level within one individual. This mini review …

The zebrafish (Danio rerio) anxiety test battery: comparison of behavioral responses in the novel tank diving and light–dark tasks following exposure to anxiogenic …

BD Fontana, N Alnassar, MO Parker - Psychopharmacology, 2022 - Springer
Rationale Triangulation of approaches (ie, using several tests of the same construct) can be
extremely useful for increasing the robustness of the findings being widely used when …

Examining behavioural test sensitivity and locomotor proxies of anxiety-like behaviour in zebrafish

A Johnson, E Loh, R Verbitsky, J Slessor… - Scientific Reports, 2023 - nature.com
This study assessed the sensitivity of four anxiety-like behaviour paradigms in zebrafish: the
novel tank dive test, shoaling test, light/dark test, and the less common shoal with novel …

Seizures induced by pentylenetetrazole in the adult zebrafish: a detailed behavioral characterization

BHM Mussulini, CE Leite, KC Zenki, L Moro, S Baggio… - PloS one, 2013 - journals.plos.org
Pentylenetetrazole (PTZ) is a common convulsant agent used in animal models to
investigate the mechanisms of seizures. Although adult zebrafish have been recently used …

Female adult zebrafish (Danio rerio) show higher levels of anxiety‐like behavior than males, but do not differ in learning and memory capacity

BD Fontana, M Cleal, MO Parker - European Journal of …, 2020 - Wiley Online Library
Zebrafish (Danio rerio) are widely used as a translational model for human neuropsychiatric
conditions. Many studies have not considered sex differences in their analyses. Here, we …