Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Astrocytes play key roles in the regulation of brain energy metabolism, which has a major
impact on brain functions, including memory, neuroprotection, resistance to oxidative stress …

The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …

Background Increased peripheral inflammation has been consistently reported in patients
with major depressive disorder (MDD). However, only few studies have explored markers of …

Depression is a common mental illness, affecting more than 300 million people worldwide.
Decades of investigation have yielded symptomatic therapies for this disabling condition but …

The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

The impact of infections and inflammation during pregnancy on the developing fetal brain
remains incompletely defined, with important clinical and research gaps. Although the …

Increasing data indicate that inflammation and alterations in glutamate neurotransmission
are two novel pathways to pathophysiology in mood disorders. The primary goal of this …

Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …