Immunological mechanisms and therapeutic targets of fatty liver diseases
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
Inflammatory pathways in alcoholic steatohepatitis
Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …
Evolving complexity of MIF signaling
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …
Hepatic consequences of COVID-19 infection. Lapping or biting?
P Portincasa, M Krawczyk, A Machill, F Lammert… - European journal of …, 2020 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19) starting last December in China
placed emphasis on liver involvement during infection. This review discusses the underlying …
placed emphasis on liver involvement during infection. This review discusses the underlying …
MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model
PV Tilstam, W Schulte, T Holowka… - The Journal of …, 2021 - Am Soc Clin Investig
Excessive inflammation drives the progression from sepsis to septic shock. Macrophage
migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict …
migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict …
Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce …
TJ Alban, D Bayik, B Otvos, A Rabljenovic… - Frontiers in …, 2020 - frontiersin.org
The application of tumor immunotherapy to glioblastoma (GBM) is limited by an
unprecedented degree of immune suppression due to factors that include high numbers of …
unprecedented degree of immune suppression due to factors that include high numbers of …
MIF family proteins in genitourinary cancer: tumorigenic roles and therapeutic potential
JC Penticuff, BL Woolbright, TM Sielecki… - Nature Reviews …, 2019 - nature.com
Genitourinary cancers encompass some of the most common solid tumours and have high
rates of morbidity and mortality. Inflammation is associated with enhanced tumorigenesis …
rates of morbidity and mortality. Inflammation is associated with enhanced tumorigenesis …
Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis
R Moreno Traspas, TS Teoh, PM Wong, M Maier… - Nature …, 2022 - nature.com
Cirrhosis is usually a late-onset and life-threatening disease characterized by fibrotic
scarring and inflammation that disrupts liver architecture and function. While it is typically the …
scarring and inflammation that disrupts liver architecture and function. While it is typically the …
Oxyberberine, a novel HO-1 agonist, effectively ameliorates oxidative stress and inflammatory response in LPS/D-GalN induced acute liver injury mice via coactivating …
G Ai, X Wu, Y Dou, R Huang, L Zhong, Y Liu… - Food and Chemical …, 2022 - Elsevier
Oxyberberine (OBB), a main gut-mediated metabolite of Phellodendron chinense Cortex
(PC), exhibits prominent protective property against acute liver injury (ALI). Heme …
(PC), exhibits prominent protective property against acute liver injury (ALI). Heme …
Metabolic dysfunction associated fatty liver disease and coronavirus disease 2019: clinical relationship and current management
Y Xu, X Yang, H Bian, M Xia - Lipids in health and disease, 2021 - Springer
Abstract The coronavirus disease 2019 (COVID-19) is caused by the severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2). At present, the COVID-19 has been …
respiratory syndrome coronavirus type 2 (SARS-CoV-2). At present, the COVID-19 has been …