Immunological mechanisms and therapeutic targets of fatty liver diseases

H Wang, W Mehal, LE Nagy, Y Rotman - Cellular & Molecular …, 2021 - nature.com
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …

Inflammatory pathways in alcoholic steatohepatitis

B Gao, MF Ahmad, LE Nagy, H Tsukamoto - Journal of hepatology, 2019 - Elsevier
Inflammatory processes are primary contributors to the development and progression of
alcoholic steatohepatitis (ASH), with severe alcoholic hepatitis characterised by non …

Evolving complexity of MIF signaling

SS Jankauskas, DWL Wong, R Bucala, S Djudjaj… - Cellular signalling, 2019 - Elsevier
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types,
including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. Altered …

Hepatic consequences of COVID-19 infection. Lapping or biting?

P Portincasa, M Krawczyk, A Machill, F Lammert… - European journal of …, 2020 - Elsevier
The outbreak of coronavirus disease 2019 (COVID-19) starting last December in China
placed emphasis on liver involvement during infection. This review discusses the underlying …

MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model

PV Tilstam, W Schulte, T Holowka… - The Journal of …, 2021 - Am Soc Clin Investig
Excessive inflammation drives the progression from sepsis to septic shock. Macrophage
migration inhibitory factor (MIF) is of interest because MIF promoter polymorphisms predict …

Glioblastoma myeloid-derived suppressor cell subsets express differential macrophage migration inhibitory factor receptor profiles that can be targeted to reduce …

TJ Alban, D Bayik, B Otvos, A Rabljenovic… - Frontiers in …, 2020 - frontiersin.org
The application of tumor immunotherapy to glioblastoma (GBM) is limited by an
unprecedented degree of immune suppression due to factors that include high numbers of …

MIF family proteins in genitourinary cancer: tumorigenic roles and therapeutic potential

JC Penticuff, BL Woolbright, TM Sielecki… - Nature Reviews …, 2019 - nature.com
Genitourinary cancers encompass some of the most common solid tumours and have high
rates of morbidity and mortality. Inflammation is associated with enhanced tumorigenesis …

Loss of FOCAD, operating via the SKI messenger RNA surveillance pathway, causes a pediatric syndrome with liver cirrhosis

R Moreno Traspas, TS Teoh, PM Wong, M Maier… - Nature …, 2022 - nature.com
Cirrhosis is usually a late-onset and life-threatening disease characterized by fibrotic
scarring and inflammation that disrupts liver architecture and function. While it is typically the …

Oxyberberine, a novel HO-1 agonist, effectively ameliorates oxidative stress and inflammatory response in LPS/D-GalN induced acute liver injury mice via coactivating …

G Ai, X Wu, Y Dou, R Huang, L Zhong, Y Liu… - Food and Chemical …, 2022 - Elsevier
Oxyberberine (OBB), a main gut-mediated metabolite of Phellodendron chinense Cortex
(PC), exhibits prominent protective property against acute liver injury (ALI). Heme …

Metabolic dysfunction associated fatty liver disease and coronavirus disease 2019: clinical relationship and current management

Y Xu, X Yang, H Bian, M Xia - Lipids in health and disease, 2021 - Springer
Abstract The coronavirus disease 2019 (COVID-19) is caused by the severe acute
respiratory syndrome coronavirus type 2 (SARS-CoV-2). At present, the COVID-19 has been …