Angiogenesis is a hallmark of wound healing, the menstrual cycle, cancer, and various
ischemic and inflammatory diseases. A rich variety of pro-and antiangiogenic molecules …

Vascular endothelial growth factor A (VEGF-A), the founding member of the vascular
permeability factor (VPF)/VEGF family of proteins, is an important angiogenic cytokine with …

The family of vascular endothelial growth factors (VEGFs) currently includes VEGF-A,-B,-C,-
D,-E, and placenta growth factor (PlGF). Several of these factors, notably VEGF-A, exist as …

Proeomics-based approaches, which examine the expressed proteins of a tissue or cell
type, complement the genome initiatives and are increasingly being used to address …

Angiogenesis is required for tumor growth and metastasis and, therefore, represents an
exciting target for cancer treatment. Angiogenesis is a complex process that is tightly …

Purpose: Vascular endothelial growth factor (VEGF) is a major mitogen for endothelial cells
and enhances vascular permeability. Enhanced VEGF secretion is found in human cancers …

The stimulation of vascular endothelial growth factor receptor-2 (VEGFR-2) by tumor-derived
VEGF represents a key event in the initiation of angiogenesis. In this work, we report that …

Background: The presence of hypoxic regions within solid tumors is associated with a more
malignant tumor phenotype and worse prognosis. To obtain a blood supply and protect …

The aggressive biology of human pancreatic adenocarcinoma has been linked with
overexpression of vascular endothelial growth factor (VEGF). Constitutive activation of the …

Vascular endothelial growth factor (VEGF) receptors (VEGFR) play a major role in tumor
angiogenesis and, thus, represent attractive targets for the development of novel anticancer …