The lens is an avascular organ suspended between the aqueous and vitreous humors of the
eye. The cellular structure is symmetric about an axis passing through its anterior and …

Advances in molecular biological and genetic technology have greatly accelerated
elucidation of the genetic contribution to age-related cataract. Epidemiological studies have …

In the ocular lens, gap junctional communication is a key component of homeostatic
mechanisms preventing cataract formation. Gap junctions in rodent lens fibers contain two …

Human age-related nuclear cataract is associated with progressive and widespread
oxidation of proteins, particularly in the centre of the lens. The reasons for the onset of …

Lens homeostasis and transparency are dependent on the function and intercellular
communication of its epithelia. While the lens epithelium is uniquely equipped with …

Age-related cataract, an opacity of the eye lens, is the leading cause of visual impairment in
the elderly, the etiology of which is related to oxidative stress damage. Oxidation of …

An adult lens contains two easily discernible, morphologically distinct compartments, the
epithelium and the fiber-cell mass. The fiber-cell mass provides the lens with its functional …

Several families of growth factors have been identified as regulators of cell fate in the
developing lens. Members of the fibroblast growth factor family are potent inducers of lens …

To understand the structural organization responsible for lens function, we have studied the
three-dimensional arrangement of cells in the lens, and the location and molecular …

PURPOSE: To evaluate the importance of lens epithelial cell death in age-related cataract.
To determine whether the large percentage of terminal deoxynucleotidyl transferase (TdT) …