Drosophila melanogaster as a model to study autophagy in neurodegenerative diseases induced by proteinopathies
S Santarelli, C Londero, A Soldano… - Frontiers in …, 2023 - frontiersin.org
Proteinopathies are a large group of neurodegenerative diseases caused by both genetic
and sporadic mutations in particular genes which can lead to alterations of the protein …
and sporadic mutations in particular genes which can lead to alterations of the protein …
Advances in cerebellar disorders: pre-clinical models, therapeutic targets, and challenges
ABSTRACT Introduction Cerebellar ataxias (CAs) represent neurological disorders with
multiple etiologies and a high phenotypic variability. Despite progress in the understanding …
multiple etiologies and a high phenotypic variability. Despite progress in the understanding …
Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage
H Homma, Y Yoshioka, K Fujita, S Shirai… - Communications …, 2024 - nature.com
Better understanding of the earliest molecular pathologies of all neurodegenerative
diseases is expected to improve human therapeutics. We investigated the earliest molecular …
diseases is expected to improve human therapeutics. We investigated the earliest molecular …
Literature-based predictions of Mendelian disease therapies
In the effort to treat Mendelian disorders, correcting the underlying molecular imbalance may
be more effective than symptomatic treatment. Identifying treatments that might accomplish …
be more effective than symptomatic treatment. Identifying treatments that might accomplish …
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation
Y Li, H Sun, X Liu, Z Hu, H Jiang, H Guo… - International …, 2023 - Elsevier
Background The temporomandibular joint osteoarthritis (TMJ-OA) is characterized by
progressive cartilage degradation, subchondral bone erosion, and chronic pain, leading to …
progressive cartilage degradation, subchondral bone erosion, and chronic pain, leading to …
On the identification of potential novel therapeutic targets for spinocerebellar ataxia type 1 (SCA1) neurodegenerative disease using EvoPPI3
A Sousa, S Rocha, J Vieira, M Reboiro-Jato… - Journal of Integrative …, 2023 - degruyter.com
Abstract EvoPPI (http://evoppi. i3s. up. pt), a meta-database for protein-protein interactions
(PPI), has been upgraded (EvoPPI3) to accept new types of data, namely, PPI from patients …
(PPI), has been upgraded (EvoPPI3) to accept new types of data, namely, PPI from patients …
Literature-based predictions of treatments for genetic disease pathology
Identifying genetic modifiers of disease-causing genes can guide drug discovery for
treatment of genetic disorders, but selecting promising drugs to test requires extensive and …
treatment of genetic disorders, but selecting promising drugs to test requires extensive and …