Preferential cochleotoxicity of cisplatin
P Prayuenyong, DM Baguley, CJ Kros… - Frontiers in …, 2021 - frontiersin.org
Cisplatin-induced ototoxicity in humans is more predominant in the cochlea than in the
vestibule. Neither definite nor substantial vestibular dysfunction after cisplatin treatment has …
vestibule. Neither definite nor substantial vestibular dysfunction after cisplatin treatment has …
Cisplatin chemotherapy and cochlear damage: Otoprotective and chemosensitization properties of polyphenols
AR Fetoni, F Paciello, D Troiani - Antioxidants & Redox Signaling, 2022 - liebertpub.com
Significance: Cisplatin is an important component of treatment regimens for different
cancers. Notwithstanding that therapeutic success often results from partial efficacy or …
cancers. Notwithstanding that therapeutic success often results from partial efficacy or …
An enhanced antioxidant strategy of astaxanthin encapsulated in ROS-responsive nanoparticles for combating cisplatin-induced ototoxicity
J Gu, X Wang, Y Chen, K Xu, D Yu, H Wu - Journal of Nanobiotechnology, 2022 - Springer
Background Excessive accumulation of reactive oxygen species (ROS) has been
documented as the crucial cellular mechanism of cisplatin-induced ototoxicity. However …
documented as the crucial cellular mechanism of cisplatin-induced ototoxicity. However …
Optimizing non-invasive functional markers for cochlear deafferentation based on electrocochleography and auditory brainstem responses
Accumulating evidence suggests that cochlear deafferentation may contribute to
suprathreshold deficits observed with or without elevated hearing thresholds, and can lead …
suprathreshold deficits observed with or without elevated hearing thresholds, and can lead …
Degranulation of murine resident cochlear mast cells: A possible factor contributing to cisplatin-induced ototoxicity and neurotoxicity
B Karayay, H Olze, AJ Szczepek - International Journal of Molecular …, 2023 - mdpi.com
Permanent hearing loss is one of cisplatin's adverse effects, affecting 30–60% of cancer
patients treated with that drug. Our research group recently identified resident mast cells in …
patients treated with that drug. Our research group recently identified resident mast cells in …
Detecting cochlear synaptopathy through curvature quantification of the auditory brainstem response
The sound-evoked electrical compound potential known as auditory brainstem response
(ABR) represents the firing of a heterogenous population of auditory neurons in response to …
(ABR) represents the firing of a heterogenous population of auditory neurons in response to …
Demyelination and Na+ Channel Redistribution Underlie Auditory and Vestibular Dysfunction in PMP22-Null Mice
Altered expression of peripheral myelin protein 22 (PMP22) results in demyelinating
peripheral neuropathy. PMP22 exhibits a highly restricted tissue distribution with marked …
peripheral neuropathy. PMP22 exhibits a highly restricted tissue distribution with marked …
Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle
X Chen, W Xiang, L Li, K Xu - International Journal of …, 2024 - journals.sagepub.com
Antioxidant 1 copper chaperone (Atox1) may contribute to preventing DDP cochlear damage
by regulating copper transport family and cell cycle proteins. A rat model of cochlear …
by regulating copper transport family and cell cycle proteins. A rat model of cochlear …
[HTML][HTML] Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells
Hearing loss is the most common form of sensory deficit. It occurs predominantly due to hair
cell (HC) loss. Mammalian HCs are terminally differentiated by birth, making HC loss …
cell (HC) loss. Mammalian HCs are terminally differentiated by birth, making HC loss …
Selected neurological complications of oncological treatment—literature overview
A Gorzelak-Magiera, A Bobola… - Oncology in Clinical …, 2022 - journals.viamedica.pl
Abstract Treatment in oncology may lead to several adverse side effects, including those
affecting the nervous system. These side effects may reduce the quality of life of patients …
affecting the nervous system. These side effects may reduce the quality of life of patients …