ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

Prior to activation of the embryonic genome, the initiating events of mammalian development
are under maternal control and include fertilization, the block to polyspermy and processing …

Parental epigenomes are established during gametogenesis. While they are largely reset
after fertilization, broad domains of Polycomb repressive complex 2 (PRC2)-mediated …

Somatic cell nuclear transfer (SCNT) cloning is the sole reproductive engineering
technology that endows the somatic cell genome with totipotency. Since the first report on …

Worldwide over 5 million children have been conceived using assisted reproductive
technology, and research has concentrated on increasing the likelihood of ongoing …

Endometriosis is a gynecological disease characterized by the presence of endometrial
glandular epithelial and stromal cells growing in the extra-uterine environment. The disease …

Recent systematic genomic studies have revealed a broad spectrum of lncRNAs that are
involved in a variety of diseases, including tumor progression, by regulating gene …

Sperm DNA damage is considered a predictive factor for the clinical outcomes of patients
undergoing ART. Laboratory evidence suggests that zygotes and developing embryos have …

It is widely accepted that the epigenome can act as the link between environmental cues,
both external and internal, to the organism and phenotype by converting the environmental …

The AID/APOBEC family of enzymes in higher vertebrates converts cytosines in DNA or RNA
to uracil. They play a role in antibody maturation and innate immunity against viruses, and …