Sex differences in pharmacokinetics and pharmacodynamics characterize many drugs and
contribute to individual differences in drug efficacy and toxicity. Sex-based differences in …

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …

In eukaryotic cells, gene transcription is regulated by sequence-specific DNA-binding
transcription factors that recognize promoter and enhancer elements near the transcriptional …

Traditional studies on the combined effects of genetics and the environment on individual
variation in disease susceptibility primarily focus on single nucleotide polymorphisms that …

Ae. aegypti mosquitoes transmit some of the most important human viral diseases that are
responsible for a significant public health burden worldwide. The small interfering RNA …

Agricultural and residential use of organophosphate (OP) pesticides has increased in recent
decades after banning some persistent pesticides. Although there is evidence of the effects …

Histone lysine‐specific demethylase 1 (LSD1) is the first discovered and reported histone
demethylase by Dr. Shi Yang's group in 2004. It is classified as a member of amine oxidase …

The term epigenetic modification denotes reversible traits of gene expression that do not
include alterations to the DNA sequence. These epigenetic alterations are responsible for …

Chronic obstructive pulmonary disease (COPD) is a global health problem. The current
therapies for COPD are poorly effective and the mainstays of pharmacotherapy are …

There is increasing interest in targeting histone N-methyl-lysine demethylases (KDMs) with
small molecules both for the generation of probes for target exploration and for therapeutic …