Mesenchymal stem cells (MSCs) are partially defined by their ability to differentiate into
tissues including bone, cartilage and adipose in vitro, but it is their trophic, paracrine and …

In the past decade, substantial evidence supports the paradigm that stem cells exert their
reparative and regenerative effects, in large part, through the release of biologically active …

Wnts are required for cardiogenesis but the role of specific Wnts in cardiac repair remains
unknown. In this report, we show that a dynamic Wnt1/βcatenin injury response activates the …

Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to
differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can …

Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-
like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) …

One of the greatest examples of integrated signal transduction is revealed by examination of
effects mediated by AKT kinase in myocardial biology. Positioned at the intersection of …

Cardiovascular diseases (CVDs) is the leading cause of high morbidity and mortality
worldwide, which emphasizes the urgent necessity to develop new pharmacotherapies. In …

On pathological stress, the heart reactivates several signaling pathways that traditionally
were thought to be operational only in the developing heart. One of these pathways is the …

Background Bone marrow mesenchymal stem cell (BMSC) transplantation represents a
promising therapeutic strategy for ischemic heart disease. However, its effects are hampered …

Secreted frizzled related protein 2 (Sfrp2) is known as an inhibitor for the Wnt signaling. In
recent studies, Sfrp2 has been reported to inhibit the activity of Xenopus homolog of …