Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

The members of the transforming growth factor β (TGF-β) superfamily are essential
regulators of cell differentiation, phenotype and function, and have been implicated in the …

Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Most myocardial pathologic conditions are associated with cardiac fibrosis, the expansion of
the cardiac interstitium through deposition of extracellular matrix (ECM) proteins. Although …

The transforming growth factor-β (TGF-β) superfamily includes several groups of
multifunctional proteins that form two major branches, namely the TGF-β–activin–nodal …

Background: The tyrosine kinase inhibitor ponatinib is the only treatment option for chronic
myelogenous leukemia patients with T315I (gatekeeper) mutation. Pharmacovigilance …

Cardiac fibrosis plays an essential role in the development of diastolic dysfunction and
contributes to heart failure with preserved ejection fraction (HFpEF). Our previous studies …

Exosomes are a group of extracellular microvesicles that deliver biologically active RNAs,
proteins, lipids and other signaling molecules to recipient cells. Classically, exosomes act as …

Background: Signaling by cAMP is organized in multiple distinct subcellular nanodomains
regulated by cAMP-hydrolyzing PDEs (phosphodiesterases). Cardiac β-adrenergic …

Abstract Purpose of Review The loss of contractile function after heart injury remains one of
the major healthcare issues of our time. One strategy to deal with this problem would be to …