Short-chain fatty acids (SCFAs), mainly acetate, propionate, and butyrate, produced by
microbial fermentation of undigested food substances are believed to play a beneficial role …

Radiotherapy has played a major role in both the curative and palliative treatment of cancer
patients for decades. However, its toxic effect to the surrounding normal healthy tissue …

Objective Radiation proctitis (RP) is a complication of pelvic radiotherapy which affects both
the host and microbiota. Herein we assessed the radiation effect on microbiota and its …

Carbon monoxide (CO) has long been considered a toxic gas but is now a recognized
bioactive gasotransmitter with potent immunomodulatory effects. Although inhaled CO is …

Studies on human intestinal injury induced by acute exposure to γ-radiation commonly rely
on use of animal models because culture systems do not faithfully mimic human intestinal …

Purpose: Cancer treatment is one of the most challenging diseases in the present era.
Among a few modalities for cancer therapy, radiotherapy plays a pivotal role in more than …

Cancer remains the second leading cause of mortality, with nearly 10 million deaths
worldwide in 2020. In many cases, radiotherapy is used for its anticancer effects. However …

The mammalian gastrointestinal tract harbors a highly complex microbial community that
comprises hundreds of different types of bacterial cells. The gastrointestinal microbiota plays …

Abdominal pelvic radiation therapy can induce acute or chronic lesions in the small bowel
wall, called radiation enteritis. Treatment of acute radiation enteritis is essentially …

Objective The purpose of this study was to give an overview of the measures used to prevent
chronic radiation proctitis (CRP) and to provide an algorithm for the treatment of CRP …