Diagnosing antiphospholipid syndrome:'extra-criteria'manifestations and technical advances

S Sciascia, MC Amigo, D Roccatello… - Nature Reviews …, 2017 - nature.com
First described in the early 1980s, antiphospholipid syndrome (APS) is a unique form of
acquired autoimmune thrombophilia in which patients present with clinical features of …

Thrombotic risk assessment in antiphospholipid syndrome: the role of new antibody specificities and thrombin generation assay

S Sciascia, S Baldovino, K Schreiber, L Solfietti… - Clinical and Molecular …, 2016 - Springer
Antiphospholipid syndrome (APS) is an autoimmune condition characterized by the
presence of antiphospholipid antibodies (aPL) in subjects presenting with thrombosis and/or …

Prevalence and associations of anti-phosphatidylserine/prothrombin antibodies with clinical phenotypes in patients with primary antiphospholipid syndrome: aPS/PT …

CA Núñez-Álvarez, G Hernández-Molina… - Thrombosis research, 2019 - Elsevier
Objective The clinical significance of anti-phosphatidylserine/prothrombin (aPS/PT) in
antiphospholipid syndrome (APS) is still controversial. We assessed the prevalence of …

Novel diagnostic and therapeutic frontiers in thrombotic anti-phospholipid syndrome

S Sciascia, M Radin, M Bazzan… - Internal and emergency …, 2017 - Springer
The anti-phospholipid syndrome (APS) is an autoimmune disorder characterized by
vascular thrombosis and/or pregnancy morbidity, associated with a persistent positivity for …

Antiphospholipid antibodies: From general concepts to its relation with malignancies

JA Gómez-Puerta, G Espinosa, R Cervera - Antibodies, 2016 - mdpi.com
Antiphospholipid syndrome (APS) is an adquired autoimmune pro-thrombotic disease
characterized by arterial and/or venous thrombosis and/or fetal losses associated with the …

Antibodies to phosphatidylserine/prothrombin (aPS/PT) enhanced the diagnostic performance in Chinese patients with antiphospholipid syndrome

S Zhang, Z Wu, W Zhang, J Zhao… - Clinical Chemistry and …, 2018 - degruyter.com
Background: Increasing evidence has highlighted the role of non-criteria antiphospholipid
antibodies (aPLs) as important supplements to the current criteria aPLs for the diagnosis of …

Can we withdraw anticoagulation in patients with antiphospholipid syndrome after seroconvertion?

S Sciascia, E Coloma-Bazán, M Radin… - Autoimmunity …, 2017 - Elsevier
The current mainstay of treatment in patients with thrombotic antiphospholipid syndrome
(APS) is long-term anticoagulation, mainly with Vitamin K antagonist agents. Some recently …

Active NET formation in Libman–Sacks endocarditis without antiphospholipid antibodies: A dramatic onset of systemic lupus erythematosus

D Appelgren, C Dahle, J Knopf, R Bilyy, V Vovk… - …, 2018 - Taylor & Francis
Although neutrophil extracellular traps (NETs) have been highlighted in several systemic
inflammatory diseases, their clinical correlates and potential pathological role remain …

Determination of thrombogenicity levels of various antiphospholipid antibodies by a modified thrombin generation assay in patients with suspected antiphospholipid …

P Bradáčová, L Slavík, A Skoumalová… - International Journal of …, 2022 - mdpi.com
Antiphospholipid syndrome (APS) is a hypercoagulable state accompanied by the presence
of heterogeneous antiphospholipid antibodies (aPL), which nonspecifically affect …

Antibodies to phosphatidylserine/prothrombin complex and the antiphospholipid syndrome

S Sciascia, ML Bertolaccini - Lupus, 2014 - journals.sagepub.com
Antibodies to prothrombin can be detected by ELISA using prothrombin coated onto
irradiated plates (aPT) or the phosphatidylserine/prothrombin complex as antigen (aPS/PT) …