Aim The present study aims to investigate the antimicrobial as well as antivirulence potential
and the principle mechanism of action of guaiacol against Pseudomonas aeruginosa …

Background Leishmaniasis is a parasitic disease associated with extensive mortality and
morbidity. The treatment for leishmaniasis is currently based on pentavalent antimonials and …

Current treatment for visceral leishmaniasis is based on drugs such as pentavalent antimony
and amphotericin B. However, this treatment remains mostly ineffective and expensive …

Protozoan parasites infect and kill millions of people worldwide every year, particularly in
developing countries where access to clean fresh water is limited. Among the most common …

Leishmania (Viannia) braziliensis is a protozoan that causes mucocutaneous leishmaniasis,
which is an infectious disease that affects more than 12 million people worldwide. The …

Inducing apoptosis is an interesting therapeutic approach to develop drugs that act against
helminthic parasites. Researchers have investigated how curcumin (CUR), a biologically …

Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and
trypanosomiasis, has led to the search and development of alternative drugs from plant …

Chagas disease and sleeping sickness are neglected tropical diseases closely related to
poverty, for which the development of plant-derived treatments has not been a promising …

Today schistosomiasis, caused mainly by the three major schistosome species (S. mansoni,
S. haematobium and S. japonicum), has for many decades and still continues to be on a …

Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a
library of natural products, we combined target-based screening on pteridine reductase 1 …