Abstract Eight coumarin derivatives (2–8) were synthesized from 7-hydroxy-4-
phenylcoumarin 1 and were evaluated for their in vitro leishmanicidal activity against …

A series of C-cinnamoyl glycosides has been synthesized in good yield by the BF 3· OEt 2
catalyzed aldol condensation of C-glycosylated acetone derivative with a variety of aromatic …

Leishmaniasis is caused by protozoan parasites belonging to the genus Leishmania and
includes cutaneous, mucocutaneous and visceral clinical forms. The drugs currently …

An in vivo study in the laboratory rat model has been carried out to monitor changes to the
tegument and gut of adult Fasciola hepatica following treatment with myrrh ('Mirazid'). Rats …

Neglected tropical diseases (NTDs) such as leishmaniasis, filariasis, trypanosomiasis, and
schistosomiasis have claimed the lives of over one billion people, mainly affecting the less …

Pomegranate (Punica granatum) fruit and roselle (Hibiscus sabdariffa) leaves have been
used in traditional medicine, including as anthelmintics. Methanolic extracts from these …

Glutathione-S-transferase also referred as GST is one of the major detoxification enzymes in
parasitic helminths. The crucial role played by GST in various chronic infections has been …

Background: Treatment of cutaneous leishmaniasis (CL) is occasionally highly resistant to
pentavalent antimonials, the gold standard in pharmacotherapy of CL. Since there is no …

Parasitic MAPKs exhibiting significant divergence with humans and playing an imperative
role in parasitic metabolic activities have been exploited from several years as important …

Herbal and traditional medicine is commonly and widely used in Palestine. There has been
no ethno pharmacological study to document the usefulness of traditional or medicinal …