CD8+ tissue resident memory T cells (TRM cells) are essential for immune defence against
pathogens and malignancies, and the molecular processes that lead to TRM cell formation …

The Nr4a family of nuclear hormone receptors is composed of three members—
Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these …

In response to pathogenic threats, naive T cells rapidly transition from a quiescent to an
activated state, yet the underlying mechanisms are incompletely understood. Using a pulsed …

Very‐low‐carbohydrate diet triggers the endogenous production of ketone bodies as
alternative energy substrates. There are as yet unproven assumptions that ketone bodies …

The nuclear orphan receptors NR4A1, NR4A2, and NR4A3 are immediate early genes that
are induced by various signals. They act as transcription factors and their activity is not …

Nr4a receptors are activated by T cell receptor (TCR) signaling and play key roles in T cell
differentiation. Which TCR signaling pathways regulate Nr4a receptors and their sensitivities …

Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Interference with immune cell proliferation represents a successful treatment strategy in T
cell–mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis …

Bats are reservoir hosts of many zoonotic viruses with pandemic potential. We utilized single-
cell transcriptome sequencing (scRNA-seq) to analyze the immune response in bat lungs …

One of the feats of adaptive immunity is its ability to recognize foreign pathogens while
sparing the self. During maturation in the thymus, T cells are selected through the binding …