Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …

MG Savelieff, G Nam, J Kang, HJ Lee, M Lee… - Chemical …, 2018 - ACS Publications
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease

K Blennow, MJ de Leon, H Zetterberg - The Lancet, 2006 - thelancet.com
Alzheimer's disease is the most common cause of dementia. Research advances have
enabled detailed understanding of the molecular pathogenesis of the hallmarks of the …

[HTML][HTML] Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

B Caballero, M Bourdenx, E Luengo, A Diaz… - Nature …, 2021 - nature.com
Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …

[HTML][HTML] A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI

JE Iglesias, JC Augustinack, K Nguyen, CM Player… - Neuroimage, 2015 - Elsevier
Automated analysis of MRI data of the subregions of the hippocampus requires
computational atlases built at a higher resolution than those that are typically used in current …

[HTML][HTML] Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders

JK Winstone, KV Pathak, W Winslow, IS Piras… - Journal of …, 2022 - Springer
Background Herbicides are environmental contaminants that have gained much attention
due to the potential hazards they pose to human health. Glyphosate, the active ingredient in …

Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease

AT Du, N Schuff, D Amend, MP Laakso… - Journal of Neurology …, 2001 - jnnp.bmj.com
OBJECTIVES To explore volume changes of the entorhinal cortex (ERC) and hippocampus
in mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared with normal …

Hippocampus and entorhinal cortex in mild cognitive impairment and early AD

C Pennanen, M Kivipelto, S Tuomainen… - Neurobiology of …, 2004 - Elsevier
Magnetic resonance imaging (MRI) has been suggested as a useful tool in early diagnosis
of Alzheimer's disease (AD). Based on MRI-derived volumes, we studied the hippocampus …

Support vector machine-based classification of Alzheimer's disease from whole-brain anatomical MRI

B Magnin, L Mesrob, S Kinkingnéhun… - Neuroradiology, 2009 - Springer
Purpose We present and evaluate a new automated method based on support vector
machine (SVM) classification of whole-brain anatomical magnetic resonance imaging to …

Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging

E Gerardin, G Chételat, M Chupin, R Cuingnet… - Neuroimage, 2009 - Elsevier
We describe a new method to automatically discriminate between patients with Alzheimer's
disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on …

Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease

D Chan, NC Fox, RI Scahill, WR Crum… - Annals of …, 2001 - Wiley Online Library
Volumetric magnetic resonance imaging analyses of 30 subjects were undertaken to
quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's …