Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Alzheimer's disease
K Blennow, MJ de Leon, H Zetterberg - The Lancet, 2006 - thelancet.com
Alzheimer's disease is the most common cause of dementia. Research advances have
enabled detailed understanding of the molecular pathogenesis of the hallmarks of the …
enabled detailed understanding of the molecular pathogenesis of the hallmarks of the …
[HTML][HTML] Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
B Caballero, M Bourdenx, E Luengo, A Diaz… - Nature …, 2021 - nature.com
Disrupted homeostasis of the microtubule binding protein tau is a shared feature of a set of
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
neurodegenerative disorders known as tauopathies. Acetylation of soluble tau is an early …
[HTML][HTML] A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI
JE Iglesias, JC Augustinack, K Nguyen, CM Player… - Neuroimage, 2015 - Elsevier
Automated analysis of MRI data of the subregions of the hippocampus requires
computational atlases built at a higher resolution than those that are typically used in current …
computational atlases built at a higher resolution than those that are typically used in current …
[HTML][HTML] Glyphosate infiltrates the brain and increases pro-inflammatory cytokine TNFα: implications for neurodegenerative disorders
Background Herbicides are environmental contaminants that have gained much attention
due to the potential hazards they pose to human health. Glyphosate, the active ingredient in …
due to the potential hazards they pose to human health. Glyphosate, the active ingredient in …
Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease
OBJECTIVES To explore volume changes of the entorhinal cortex (ERC) and hippocampus
in mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared with normal …
in mild cognitive impairment (MCI) and Alzheimer's disease (AD) compared with normal …
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
C Pennanen, M Kivipelto, S Tuomainen… - Neurobiology of …, 2004 - Elsevier
Magnetic resonance imaging (MRI) has been suggested as a useful tool in early diagnosis
of Alzheimer's disease (AD). Based on MRI-derived volumes, we studied the hippocampus …
of Alzheimer's disease (AD). Based on MRI-derived volumes, we studied the hippocampus …
Support vector machine-based classification of Alzheimer's disease from whole-brain anatomical MRI
B Magnin, L Mesrob, S Kinkingnéhun… - Neuroradiology, 2009 - Springer
Purpose We present and evaluate a new automated method based on support vector
machine (SVM) classification of whole-brain anatomical magnetic resonance imaging to …
machine (SVM) classification of whole-brain anatomical magnetic resonance imaging to …
Multidimensional classification of hippocampal shape features discriminates Alzheimer's disease and mild cognitive impairment from normal aging
We describe a new method to automatically discriminate between patients with Alzheimer's
disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on …
disease (AD) or mild cognitive impairment (MCI) and elderly controls, based on …
Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease
D Chan, NC Fox, RI Scahill, WR Crum… - Annals of …, 2001 - Wiley Online Library
Volumetric magnetic resonance imaging analyses of 30 subjects were undertaken to
quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's …
quantify the global and temporal lobe atrophy in semantic dementia and Alzheimer's …