Schizophrenia is a debilitating mental illness which involves three groups of symptoms, ie,
positive, negative and cognitive, and has major public health implications. According to …

The introduction of allosteric receptor–receptor interactions in G protein-coupled receptor
(GPCR) heteroreceptor complexes of the central nervous system (CNS) gave a new …

Two major types of intercellular communication are found in the central nervous system
(CNS), namely wiring transmission (point-to-point communication, the prototype being …

Treatment resistant schizophrenia (TRS) is characterized by a lack of, or suboptimal
response to, antipsychotic agents. The biological underpinnings of this clinical condition are …

Evidence for striatal A2A‐D2 heterodimers has led to a new perspective on molecular
mechanisms involved in schizophrenia and Parkinson's disease. Despite the increasing …

The dopamine (DA) neuron system most relevant for schizophrenia is the meso-limbic-
cortical DA system inter alia densely innervating subcortical limbic regions. The field of …

Abstract Dopamine D2 receptor (D2R)–oxytocin receptor (OTR) interactions exist within
heterocomplexes with facilitatory effects on D2R recognition and Gi/o coupling. In this work …

This perspective article provides observations supporting the view that nigro-striatal
dopamine neurons and meso-limbic dopamine neurons mainly communicate through short …

It is now generally accepted that astrocytes are active players in synaptic transmission, so
that a neurocentric perspective of the integrative signal communication in the central …

Abstract Adenosine 2A receptor (A2AR) agonists were indicated to reduce cocaine reward
and cocaine seeking mainly through activation of antagonistic allosteric A2AR-dopamine …