Despite intensive research on peroxisome biochemistry, the role of glutathione in
peroxisomal redox homeostasis has remained a matter of speculation for many years, and …

Mitochondria are critical for providing energy to maintain cell viability. Oxidative
phosphorylation involves the transfer of electrons from energy substrates to oxygen to …

Peroxisomes are highly dynamic, oxidative organelles with key metabolic functions in
cellular lipid metabolism, such as the β-oxidation of fatty acids and the synthesis of myelin …

Abstract Hydrogen peroxide (H 2 O 2), a natural metabolite commonly found in aerobic
organisms, plays a crucial role in numerous cellular signaling processes. One of the key …

Despite the crucial role of peroxisomes in cellular redox maintenance, little is known about
how these organelles transport redox metabolites across their membrane. In this study, we …

In the cytosol of human cells under low oxidative loads, hydrogen peroxide is confined to
microdomains around its supply sites, due to its fast consumption by peroxiredoxins. So are …

Hepatic ischemia-reperfusion injury (HIRI) adversely affects liver transplant and resection
outcomes. Recently, ferroptosis has been associated with HIRI. Dexmedetomidine (Dex), a …

Mitochondria are widely believed to be major O2•-and H2O2 suppliers to the cytosol, but the
supply rates in vivo under physiological conditions can only be indirectly estimated …