Polysialic acid (PSA) is a linear homopolymer of α2-8-N acetylneuraminic acid whose major
carrier in vertebrates is the neural cell adhesion molecule (NCAM). PSA serves as a potent …

Alzheimer's disease (AD) is a devastating neurological condition characterized by a
progressive decline in cognitive performance accompanied by behavioral and psychological …

Adult hippocampal neurogenesis declines in aging rodents and primates. Aging humans are
thought to exhibit waning neurogenesis and exercise-induced angiogenesis, with a resulting …

Background Essentially all knowledge about adult hippocampal neurogenesis in humans
still comes from one seminal study by Eriksson et al. in 1998, although several others have …

Depression is a devastating and prevalent disease, with profound effects on neural structure
and function; however the etiology and neuropathology of depression remain poorly …

Studies on brain plasticity have undertaken different roads, tackling a wide range of
biological processes: from small synaptic changes affecting the contacts among neurons at …

By mediating cell adhesion and signal transduction, the neural cell adhesion molecule
(NCAM) regulates neurite outgrowth, fasciculation and target recognition in the developing …

Recent findings have significantly advanced our understanding the mechanisms of memory
formation. Most of these advances stemmed from behavioural pharmacology research …

Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are
mostly found as terminal residues in glycan structures of glycoconjugates including both …

Adult neurogenesis in the mammalian hippocampus is a well-known phenomenon.
However, it remains controversial as to what extent adult neurogenesis actually occurs in the …