Health-related conditions often differ qualitatively or quantitatively between individuals of
different birth-assigned sexes and gender identities, and/or with different gendered …

Although most patients with chronic pain are women, the preclinical literature regarding pain
processing and the pathophysiology of chronic pain has historically been derived …

INTRODUCTION Proteins are essential functional units of the human body and represent
the largest class of drug targets. RATIONALE Broad-capture proteomics has the potential to …

The Genotype-Tissue Expression (GTEx) project was established to characterize genetic
effects on the transcriptome across human tissues and to link these regulatory mechanisms …

INTRODUCTION Many complex human phenotypes, including diseases, exhibit sex-
differentiated characteristics. These sex differences have been variously attributed to …

The goal of sex and gender analysis is to promote rigorous, reproducible and responsible
science. Incorporating sex and gender analysis into experimental design has enabled …

Precision Medicine implies a deep understanding of inter-individual differences in health
and disease that are due to genetic and environmental factors. To acquire such …

Prediction of disease risk is an essential part of preventative medicine, often guiding clinical
management. Risk prediction typically includes risk factors such as age, sex, family history of …

Males and females present differences in complex traits and in the risk of a wide array of
diseases. Genotype by sex (GxS) interactions are thought to account for some of these …

Sex differences manifest in many diseases and may drive sex-specific therapeutic
responses. To understand the molecular basis of sex differences, we evaluated sex-biased …