Background Cystic fibrosis (CF) is a genetic disease caused by mutations in the gene
encoding the cystic fibrosis transmembrane conductance regulator (CFTR), which results in …

Mucus layers (McLs) are on the front line of the human defense system that protect us from
foreign abiotic/biotic particles (eg, airborne virus SARS-CoV-2) and lubricates our organs …

Few human genetic diseases can rely on the availability of as many and as diverse animal
models as cystic fibrosis (CF), a multiorgan syndrome caused by functional absence of cystic …

In cystic fibrosis (CF), defects in the CF transmembrane conductance regulator (CFTR)
channel lead to an acidic airway surface liquid (ASL), which compromises innate defence …

Airway mucus obstruction is the main cause of morbidity in cystic fibrosis, a disease caused
by mutations in the CFTR Cl− channel. Activation of non-CFTR Cl− channels such as …

After more than two decades since clinical trials tested the first use of recombinant adeno-
associated virus (rAAV) to treat cystic fibrosis (CF) lung disease, gene therapy for this …

Pseudomonas aeruginosa has long been established as the most prevalent respiratory
pathogen in Cystic Fibrosis (CF) patients, with opportunistic infection causing profound …

Cystic fibrosis (CF) is a genetic disease hallmarked by aberrant ion transport that results in
delayed mucus clearance, chronic infection, and progressive lung function decline. Several …

Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the cystic
fibrosis transmembrane conductance regulator (CFTR) gene, responsible for the synthesis …

The organization of the normal airway mucus system differs in small experimental animals
from that in humans and large mammals. To address normal murine airway mucociliary …