Abstract The last decade (2013–2023) has seen unprecedented successes in the clinical
translation of therapeutic antisense oligonucleotides (ASOs). Eight such molecules have …

Background Parkinson's disease (PD) is a degenerative neurological condition marked by
the gradual loss of dopaminergic neurons in the substantia nigra pars compacta. The …

Alzheimer's disease (AD) is a complex multifactorial disorder that poses a substantial
burden on patients, caregivers, and society. Considering the increased aging population …

ABSTRACT Introduction: Alzheimer's Disease (AD) is a progressive neurodegenerative
pathology characterized by the presence of neuritic plaques and neurofibrillary tangles. The …

Precursor messenger RNA (pre-mRNA) splicing is a fundamental step in eukaryotic gene
expression that systematically removes non-coding regions (introns) and ligates coding …

Neurodegenerative diseases are characterized by progressive nervous system dysfunction,
which affects over 90,000 people every year. Although numerous contrast agents and …

Alterations in amyloid beta precursor protein (APP) have been implicated in cognitive
decline in Alzheimer's disease (AD), which is accelerated in Down syndrome/Trisomy 21 …

Dementia is described as the fifth leading cause of death worldwide and Alzheimer's
disease (AD) is recognized as the most common, causing a huge impact on health costs and …

A facile brain drug delivery system for Alzheimer's disease, the Magnetic iron oxide (Fe3O4)
nanoparticles loaded with polyethylene glycol-polylactide-polyglycolide co-polymer …

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease that
constitutes the third most common cause of death among elderly individuals. AD patients …