Psychosis in Alzheimer disease—mechanisms, genetics and therapeutic opportunities

Z Ismail, B Creese, D Aarsland, HC Kales… - Nature Reviews …, 2022 - nature.com
Psychosis is a common and distressing symptom in people with Alzheimer disease, and few
safe and effective treatments are available. However, new approaches to symptom …

Brain mechanisms underlying neuropsychiatric symptoms in Alzheimer's disease: a systematic review of symptom-general and–specific lesion patterns

Y Chen, M Dang, Z Zhang - Molecular Neurodegeneration, 2021 - Springer
Neuropsychiatric symptoms (NPSs) are common in patients with Alzheimer's disease (AD)
and are associated with accelerated cognitive impairment and earlier deaths. This review …

Assessment and management of behavioral and psychological symptoms of dementia

HC Kales, LN Gitlin, CG Lyketsos - Bmj, 2015 - bmj.com
Behavioral and psychological symptoms of dementia include agitation, depression, apathy,
repetitive questioning, psychosis, aggression, sleep problems, wandering, and a variety of …

Causes of nursing home placement for older people with dementia: a systematic review and meta-analysis

S Toot, T Swinson, M Devine, D Challis… - International …, 2017 - cambridge.org
Background: Up to half of people with dementia in high income countries live in nursing
homes and more than two-thirds of care home residents have dementia. Fewer than half of …

Best practice in the management of behavioural and psychological symptoms of dementia

OP Tible, F Riese, E Savaskan… - Therapeutic advances …, 2017 - journals.sagepub.com
Behavioural and psychological symptoms of dementia (BPSD) occur in most patients with
dementia. They cause great suffering in patients and caregivers, sometimes more so than …

[HTML][HTML] Impact of person-centred care training and person-centred activities on quality of life, agitation, and antipsychotic use in people with dementia living in nursing …

C Ballard, A Corbett, M Orrell, G Williams… - PLoS …, 2018 - journals.plos.org
Background Agitation is a common, challenging symptom affecting large numbers of people
with dementia and impacting on quality of life (QoL). There is an urgent need for evidence …

Alzheimer's disease

C Ballard, S Gauthier, A Corbett, C Brayne, D Aarsland… - the Lancet, 2011 - thelancet.com
An estimated 24 million people worldwide have dementia, the majority of whom are thought
to have Alzheimer's disease. Thus, Alzheimer's disease represents a major public health …

Neuropsychiatric symptoms in Alzheimer's disease

CG Lyketsos, MC Carrillo, JM Ryan… - Alzheimer's & …, 2011 - Elsevier
Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related
dementias. Once thought to emerge primarily in people with late-stage disease, these …

Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial

AP Porsteinsson, LT Drye, BG Pollock, DP Devanand… - Jama, 2014 - jamanetwork.com
Importance Agitation is common, persistent, and associated with adverse consequences for
patients with Alzheimer disease. Pharmacological treatment options, including …

Management of neuropsychiatric symptoms of dementia in clinical settings: recommendations from a multidisciplinary expert panel

HC Kales, LN Gitlin, CG Lyketsos… - Journal of the …, 2014 - Wiley Online Library
Noncognitive neuropsychiatric symptoms (NPS) of dementia (aggression, agitation,
depression, anxiety, delusions, hallucinations, apathy, disinhibition) affect individuals with …