Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

Rejection of the Kidney Allograft | New England Journal of Medicine Skip to main content The
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Cytotoxic T lymphocytes (CTLs) are important immune cells, and their activation is a key step
for cancer immunotherapy. Precise evaluation of CTL activity in vivo provides a powerful tool …

This article provides a comprehensive, up-to-date review of methods to prevent early and
late renal-allograft loss and to improve long-term outcomes in patients. The authors focus …

Kidney transplantation is the best possible treatment for many patients with end-stage renal
failure, but progressive dysfunction and eventual allograft loss with return to dialysis is …

Autoimmune hepatitis (AIH) is a rare disease of unclear etiology characterized by loss of self‐
tolerance that can lead to liver injury, cirrhosis, and acute liver failure. First‐line treatment …

Background The causes and clinical course of acute rejection vary, and it is not possible to
predict graft outcome reliably on the basis of available clinical, pathological, and genetic …

Noninvasive biomarkers are needed to assess immune risk and ultimately guide therapeutic
decision-making following kidney transplantation. A requisite step toward these goals is …

A half-century has elapsed since the first transplantation, and this procedure is now
accepted as the treatment of choice for end-stage organ failure. This article reviews the …

The cytotoxic granzyme B (GrB)/perforin pathway has been traditionally viewed as a primary
mechanism that is used by cytotoxic lymphocytes to eliminate allogeneic, virally infected …