Sleep has a homeostatic role in the regulation of the immune system and serves to constrain
activation of inflammatory signalling and expression of cellular inflammation. In patients with …

Brain-derived neurotrophic factor (BDNF) is a neurotrophin regulating synaptic plasticity,
neuronal excitability, and nociception. It seems to be one of the key molecules in interactions …

Sleep loss heightens pain sensitivity, but the pathways underlying this association are not
known. Given that experimental sleep disruption induces increases in cellular inflammation …

Objectives To investigate the quality of sleep and the psychological profiles of a large cohort
of Italian patients with burning mouth syndrome (BMS) and to clarify the relationships …

Obstructive sleep apnea (OSA) is a disorder characterized by chronic intermittent hypoxia
and sleep fragmentation due to recurring airway collapse during sleep. It is highly prevalent …

Background We investigated the influence of sleeplessness and number of insomnia
symptoms on the probability of recovery from chronic low back pain (LBP), and the possible …

Insomnia and chronic pain are highly prevalent conditions and are often comorbid. Somatic
complaints other than pain are also often observed in insomnia. Poor sleep and pain are …

Twin studies have consistently found that genetic factors explain a substantial proportion of
the variance for insomnia. However, studies vary widely in their heritability estimates …

Musculoskeletal pain is common and often occurs at multiple sites. Persons with chronic
widespread pain (CWP) often report disturbed sleep. Until recently, the relationship between …

Background Few studies have examined the relationship between falls and pain, insomnia
and depressive symptoms which are common and risk factors in older adults. We aimed to …