Dopamine, immunity, and disease
B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …
regulating many processes including reward, movement, and cognition. Dopamine also …
[HTML][HTML] The bidirectional relationship of depression and inflammation: double trouble
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …
Inflammatory processes have been implicated in the pathophysiology of depression. It is …
[HTML][HTML] A Delphi-method-based consensus guideline for definition of treatment-resistant depression for clinical trials
L Sforzini, C Worrell, M Kose, IM Anderson… - Molecular …, 2022 - nature.com
Criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD)
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …
as subtypes of major depressive disorder (MDD) are not unequivocally defined. In the …
[HTML][HTML] Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression
B Guo, M Zhang, W Hao, Y Wang, T Zhang… - Translational …, 2023 - nature.com
Mood disorders are associated with elevated inflammation, and the reduction of symptoms
after multiple treatments is often accompanied by pro-inflammation restoration. A variety of …
after multiple treatments is often accompanied by pro-inflammation restoration. A variety of …
Management of treatment-resistant depression: challenges and strategies
D Voineskos, ZJ Daskalakis… - … disease and treatment, 2020 - Taylor & Francis
Abstract Treatment-resistant depression (TRD) is a subset of Major Depressive Disorder
which does not respond to traditional and first-line therapeutic options. There are several …
which does not respond to traditional and first-line therapeutic options. There are several …
[HTML][HTML] Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression
T Behl, T Rana, GH Alotaibi, M Shamsuzzaman… - Biomedicine & …, 2022 - Elsevier
Depression is one of the most debilitating psychiatric disorders affecting people of all ages
worldwide. Despite significant heterogeneity between studies, increased inflammation and …
worldwide. Despite significant heterogeneity between studies, increased inflammation and …
Depression and obesity: evidence of shared biological mechanisms
Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …
tend to co-occur within individuals. The relationship between these conditions is …
[HTML][HTML] Prognosis and improved outcomes in major depression: a review
C Kraus, B Kadriu, R Lanzenberger… - Translational …, 2019 - nature.com
Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …
Presently, no clinically relevant tools have been established for stratifying subgroups or …
Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis
JJ Liu, YB Wei, R Strawbridge, Y Bao, S Chang… - Molecular …, 2020 - nature.com
Predicting antidepressant treatment response has been a clinical challenge for major
depressive disorder (MDD). The inflammation hypothesis of depression suggests that …
depressive disorder (MDD). The inflammation hypothesis of depression suggests that …