The over expression of EGFR has been recognized as the driver mechanism in the
occurrence and progression of carcinomas such as lung cancer, breast cancer, pancreatic …

Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

Abstract A series of 5-aryl-3-(4-oxo-2-phenylquinazolin-3 (4 H)-yl)-2-(pyridin-4-yl) thiazolidin-
4-ones were synthesized and evaluated for their antibacterial and antifungal activities …

Cancer, which has been cursed for human beings for long time is considered as one of the
leading causes of morbidity and mortality across the world. In spite of different types of …

Introduction: EGFR is the receptor for epidermal growth factor (EGF) and belongs to the
protein tyrosine kinase (PTK) receptor. It is closely related to the inhibition of tumor cell …

A transition-metal-free synthesis of quinazolin-4-ones by Cs2CO3-promoted SNAr reaction
of ortho-fluorobenzamides with amides followed by cyclization in dimethyl sulfoxide has …

Background: Cancer is the world's third deadliest disease. Despite the availability of
numerous treatments, researchers are focusing on the development of new drugs with no …

Four series of thiopyranopyrimidine AZD9291 derivatives containing acrylamide structure
were designed, synthesized and evaluated for their antiproliferative activity against A549 …

G-quadruplexes (GQs) have become valid targets for anticancer studies in recent decades
due to their multifaceted biological function. Herewith, we aim to quantify interactions of …

Cancer is one of the major causes of human mortality worldwide. A number of approved
antineoplastic medications and treatment regimens are already working in the field, and …