The skin, being the barrier organ of the body, is constitutively exposed to various stimuli
impacting its morphology and function. Senescent cells have been found to accumulate with …

Cellular senescence and aging result in a reduced ability to manage persistent types of
inflammation. Thus, the chronic low-level inflammation associated with aging phenotype is …

Hair follicle stem cells (HFSCs) are among the most widely available resources and most
frequently approved model systems used for studying adult stem cells. HFSCs are …

The human skin is exposed daily to different environmental factors such as air pollutants and
ultraviolet (UV) light. Air pollution is considered a harmful environmental risk to human skin …

Aging in humans is intricately linked with alterations in circadian rhythms concomitant with
physiological decline and stem cell exhaustion. However, whether the circadian machinery …

Skin disorders showing abnormal pigmentation are often difficult to manage because of their
uncertain etiology or pathogenesis. Abnormal pigmentation is a common symptom …

The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators
by its versatility of functions and mechanisms of action, which include the regulation of …

Photoaging is characterized by a chronic inflammatory response to UV light. One of the most
prominent features of cutaneous photoaging is wrinkling, which is due primarily to a loss of …

The skin is the most-extensive and-abundant tissue in the human body. Like many organs,
as we age, human skin experiences gradual atrophy in both the epidermis and dermis. This …

Skin aging is a multi-factorial process that affects nearly every aspect of skin biology and
function. With age, an impairment of structures, quality characteristics, and functions of the …