Psychiatric disorders associated with psychological trauma, stress and anxiety are a highly
prevalent and increasing cause of morbidity worldwide. Current therapeutic approaches …

Emerging evidence suggests that astrocyte loss is one of the most important pathological
features in the hippocampus of patients with major depressive disorder (MDD) and …

• Depression is common among adolescents in Canada and has the potential to negatively
affect longterm function and quality of life; despite this, in most affected adolescents …

Objective To enhance the quality of care and clinical outcomes for children and adolescents
with major depressive disorder (MDD) and persistent depressive disorder (PDD). The aims …

The COVID-19 pandemic has raised huge concerns for the mental health of an entire
generation of children. But the pandemic may represent only the tip of a mental health …

Importance Antidepressants are increasingly prescribed to pediatric patients with unipolar
depression, but little is known about the risk of treatment-emergent mania. Previous …

Research into mental health interventions is at an inflection point. There is an ever-growing
range of treatments and prevention initiatives with evidence of efficacy. However, strands of …

Depression is a major global health issue that urgently requires innovative and precise
treatment options. In this context, saikosaponin has emerged as a promising candidate …

As depression is projected to become the leading mental disease burden globally by 2030,
understanding the underlying pathology, as well as screening potential anti-depressants …

Background: Ketamine is an emerging treatment for treatment-resistant depression (TRD)
associated with rapid and robust improvements in depressive symptoms and suicidality …