The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of
the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue …

A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Blood flow into the brain is dynamically regulated to satisfy the changing metabolic
requirements of neurons, but how this is accomplished has remained unclear. Here we …

Functional magnetic resonance imaging (fMRI) provides a unique view of the working
human mind. The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects …

Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …

Functional hyperemia, a regional increase of blood flow triggered by local neural activation,
is used to map brain activity in health and disease. However, the spatial-temporal dynamics …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Abstract Pannexin-1 (Panx1) channels have been shown to regulate leukocyte trafficking
and tissue inflammation but the mechanism of Panx1 in chronic vascular diseases like …

Efficient insulin secretion requires a well-functioning pancreatic islet microvasculature. The
dense network of islet capillaries includes the islet pericyte, a cell that has barely been …

The brain possesses two intricate mechanisms that fulfill its continuous metabolic needs:
cerebral autoregulation, which ensures constant cerebral blood flow over a wide range of …