Parkinson's disease is the second most common neurodegenerative disease and its
prevalence has been projected to double over the next 30 years. An accurate diagnosis of …

In this review, the clinical features of Parkinson's disease, both motor and non‐motor, are
described in the context of the progression of the disease. Also briefly discussed are the …

For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson's
disease has increased substantially in the past decade. The entire gastrointestinal tract is …

Normal maintenance of human motivation depends on the integrity of subcortical structures
that link the prefrontal cortex with the limbic system. Structural and functional disruption of …

Abstract Purpose of Review The sense of smell is today one of the focuses of interest in
aging and neurodegenerative disease research. In several neurodegenerative diseases …

Non motor symptoms (NMS) represent a significant burden in Parkinson's disease (PD) with
numerous studies highlighting the importance of NMS both in “pre-motor” phase of PD as …

We conducted a systematic review and meta‐analysis aimed at establishing robust
prevalence estimates and identifying clinical correlates of fatigue in PD. From 2,459 titles …

Parkinson's disease is highly heterogeneous in early clinical features and later outcomes.
This makes classifying subgroups of PD relevant to clinical research and practice …