Building on our previous work on ibrutinib-based reversible covalent Bruton's tyrosine
kinase (BTK) PROTACs, we explored a different irreversible BTK inhibitor poseltinib as the …

Background Although the anti-HER2 antibody trastuzumab augments patient survival in
HER2+ breast cancer, a relevant number of patients progress to this treatment. In this …

Multiple myeloma (MM) is a common hematological malignancy. Although recent clinical
applications of immunomodulatory drugs, proteasome inhibitors and CD38-targeting …

A novel class of protein misfolding characterized by either the formation of non-native
noncovalent lasso entanglements in the misfolded structure or loss of native entanglements …

Photopharmacology is an emerging field that uses light to precisely control drug activity. This
strategy promises to improve drug specificity for reducing off-target effects. Proteolysis …

Alzheimer's disease (AD) is one of the most common chronic neurodegenerative diseases.
Hyperphosphorylated tau plays an indispensable role in neuronal dysfunction and synaptic …

The tripartite motif (TRIM) protein family members have been implicated in a multitude of
physiologies and pathologies in different tissues. With diverse functions in cellular …

Our previous research has revealed phosphoglycerate kinase 1 (PGK1) enhances
tumorigenesis and sorafenib resistance of kidney renal clear cell carcinoma (KIRC) by …

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have the
capability to induce specific protein degradation. While playing a revolutionary role in …

MDM2 genes amplification or altered expression is commonly observed in various cancers
bearing wild-type TP53. Directly targeting the p53-binding pocket of MDM2 to activate the …