Pancreatic cancer is one of the major malignancies and causes of mortality worldwide. E3
ubiquitin-protein ligases transfer activated ubiquitin from ubiquitin-conjugating enzymes to …

Directly targeted KRAS inhibitors are now facing resistance problems, which might be
partially solved by the combination of SOS1 inhibitors with KRAS inhibitors. However, this …

Methylation of adenine N6 (m6A) is the most frequent RNA modification. On mRNA, it is
catalyzed by the METTL3–14 heterodimer complex, which plays a key role in acute myeloid …

Microtubules are pivotal in diverse cellular functions encompassing cell signaling,
morphology, intracellular trafficking, and cell mitosis/division. They are validated targets for …

Photopharmacology is an emerging field that uses light to precisely control drug activity. This
strategy promises to improve drug specificity for reducing off-target effects. Proteolysis …

Multiple myeloma (MM) is a common hematological malignancy. Although recent clinical
applications of immunomodulatory drugs, proteasome inhibitors and CD38-targeting …

Esophageal cancer is associated with a dismal prognosis. The armamentarium of approved
drugs is focused on chemotherapy with modest therapeutic benefit. Recently, checkpoint …

A novel class of protein misfolding characterized by either the formation of non-native
noncovalent lasso entanglements in the misfolded structure or loss of native entanglements …

Alzheimer's disease (AD) is one of the most common chronic neurodegenerative diseases.
Hyperphosphorylated tau plays an indispensable role in neuronal dysfunction and synaptic …

Our previous research has revealed phosphoglycerate kinase 1 (PGK1) enhances
tumorigenesis and sorafenib resistance of kidney renal clear cell carcinoma (KIRC) by …