Machine learning in the identification, prediction and exploration of environmental toxicology: Challenges and perspectives
X Wu, Q Zhou, L Mu, X Hu - Journal of Hazardous Materials, 2022 - Elsevier
Over the past few decades, data-driven machine learning (ML) has distinguished itself from
hypothesis-driven studies and has recently received much attention in environmental …
hypothesis-driven studies and has recently received much attention in environmental …
[HTML][HTML] Systems toxicology to advance human and environmental hazard assessment: A roadmap for advanced materials
Abstract Ideally, a Systems Toxicology (ST) approach is aimed at by (eco) toxicologists, ie a
multidisciplinary area incorporating classical toxicological concepts with omics technologies …
multidisciplinary area incorporating classical toxicological concepts with omics technologies …
Chlorinated organophosphate flame retardants impair the lung function via the IL-6/JAK/STAT signaling pathway
H Zhu, H Zhang, K Lu, S Yang, X Tang… - Environmental …, 2022 - ACS Publications
Toxicological studies have revealed the adverse impacts of organophosphate flame
retardants (OPFRs) on the respiratory system, while there is a lack of epidemiological …
retardants (OPFRs) on the respiratory system, while there is a lack of epidemiological …
Toxicogenomics Data for Chemical Safety Assessment and Development of New Approach Methodologies: An Adverse Outcome Pathway‐Based Approach
Mechanistic toxicology provides a powerful approach to inform on the safety of chemicals
and the development of safe‐by‐design compounds. Although toxicogenomics supports …
and the development of safe‐by‐design compounds. Although toxicogenomics supports …
Multiomics point of departure (moPOD) modeling supports an adverse outcome pathway network for ionizing radiation
While adverse biological effects of acute high-dose ionizing radiation have been extensively
investigated, knowledge on chronic low-dose effects is scarce. The aims of the present study …
investigated, knowledge on chronic low-dose effects is scarce. The aims of the present study …
Xenobiotic-sensing nuclear receptors as targets for phthalates-induced lung injury and antagonism of lycopene
YS Shi, Y Zhao, XN Li, MZ Li, JL Li - Chemosphere, 2023 - Elsevier
Phthalates are extensively used in the production of plastics products and have been
verified to induce lung injury. Lycopene (LYC) has proved an effective preventive and can …
verified to induce lung injury. Lycopene (LYC) has proved an effective preventive and can …
[HTML][HTML] Identifying microRNAs that drive BaP-induced pulmonary effects: Multiple patterns of mechanisms underlying activation of the toxicity pathways
Y Jin, Q Zhang, Y Liu, H Guan, Y Shou, C Du… - Environment …, 2022 - Elsevier
MiRNAs are widely acknowledged as regulating gene expression and thus, being involved
in broad biological functions, environmental responses, and the process of diseases …
in broad biological functions, environmental responses, and the process of diseases …
Health risk assessment of cadmium exposure by integration of an in silico physiologically based toxicokinetic model and in vitro tests
Y Zhang, Z Liu, Z Wang, H Gao, Y Wang, M Cui… - Journal of Hazardous …, 2023 - Elsevier
Cadmium (Cd) is a common environmental pollutant that can damage multiple organs,
including the kidney. To prevent renal effects, international authorities have set health-based …
including the kidney. To prevent renal effects, international authorities have set health-based …
Pulmonary hazard identifications of Graphene family nanomaterials: adverse outcome pathways framework based on toxicity mechanisms
X Ding, Y Pu, M Tang, T Zhang - Science of The Total Environment, 2023 - Elsevier
Graphene-family nanomaterials (GFNs) are revolutionary new nanomaterials that have
attracted significant attention in the field of nanomaterials, but the ensuing problems lie in …
attracted significant attention in the field of nanomaterials, but the ensuing problems lie in …
Pathway-dependent toxic interaction between polystyrene microbeads and methylmercury on the brackish water flea Diaphanosoma celebensis: Based on mercury …
JW Yoo, TJ Choi, JS Park, J Kim, S Han, CB Kim… - Journal of Hazardous …, 2023 - Elsevier
Given their worldwide distribution and toxicity to aquatic organisms, methylmercury (MeHg)
and microplastics (MP) are major pollutants in marine ecosystems. Although they commonly …
and microplastics (MP) are major pollutants in marine ecosystems. Although they commonly …