Redox regulation in aging lungs and therapeutic implications of antioxidants in COPD

H Kiyokawa, Y Hoshino, K Sakaguchi, S Muro, J Yodoi - Antioxidants, 2021 - mdpi.com
Mammals, including humans, are aerobic organisms with a mature respiratory system to
intake oxygen as a vital source of cellular energy. Despite the essentiality of reactive oxygen …

The ACE2 activator diminazene aceturate ameliorates colitis by repairing the gut-vascular barrier in mice

C Zhang, X Cao, H Wang, Z Li, Y Zhang - Microvascular Research, 2023 - Elsevier
Alleviating vascular barrier injury improves colitis. Angiotensin converting enzyme
2/angiotensin 1-7/Mas receptor (ACE2/Ang1-7/MasR) axis-related drugs have various …

Exploring redox imbalance and inflammation for asthma therapy

M Barnabas, OJ Awakan, DE Rotimi, MA Akanji… - Molecular Biology …, 2023 - Springer
Background: Asthma is a prolonged inflammatory disorder of the airways, that affects an
estimated 300 million people worldwide. Asthma is triggered by numerous endogenous and …

Genome-wide RNAi screening identifies novel pathways/genes involved in oxidative stress and repurposable drugs to preserve cystic fibrosis airway epithelial cell …

J Checa, I Martínez-González, M Maqueda… - Antioxidants, 2021 - mdpi.com
Recurrent infection-inflammation cycles in cystic fibrosis (CF) patients generate a highly
oxidative environment, leading to progressive destruction of the airway epithelia. The …

TNFRSF1B Signaling Blockade Protects Airway Epithelial Cells from Oxidative Stress

J Checa, P Fiol, M Guevara, JM Aran - Antioxidants, 2024 - mdpi.com
Progressive respiratory airway destruction due to unresolved inflammation induced by
periodic infectious exacerbation episodes is a hallmark of cystic fibrosis (CF) lung pathology …

The OxrA protein of Aspergillus fumigatus is required for the oxidative stress response and fungal pathogenesis

P Zhai, L Shi, G Zhong, J Jiang, J Zhou… - Applied and …, 2021 - Am Soc Microbiol
An efficient reactive oxygen species (ROS) detoxification system is vital for the survival of the
pathogenic fungus Aspergillus fumigatus within the host high-ROS environment of the host …

Postprocedural clinical and laboratory evaluation of sheep submitted to different intrabdominal pressures during laparoscopy

LV de Gouvêa, TRS Leite, PRL do Nascimento… - Small Ruminant …, 2023 - Elsevier
The sheep experimental model is increasingly being used in laparoscopy, and there is a
need to ensure animal welfare during and after the procedures. Therefore, the present study …

Association between dietary carotenoid intakes and the risk of asthma in adults: a cross-sectional study of NHANES, 2007–2012

W Zhang, W Li, J Du - BMJ open, 2022 - bmjopen.bmj.com
Objective To investigate the association between dietary carotenoid intake and asthma
using data from a nationally representative sample of US adults. Design Cross-section …

Natural compounds as inhibitors of thioredoxin reductase (TrxR1)

EG Chupakhin, MY Krasavin - Russian Chemical Bulletin, 2022 - Springer
Recent achievements in the area of studying biological activity of new natural compounds
toward thioredoxin reductase 1 (TrxR1) are considered. The most important chemotypes of …

Intimate intertwining of the pathogenesis of hypoxia and systemic sclerosis: A transcriptome integration analysis

X He, Y Shi, Z Zeng, B Tang, X Xiao, J Yu… - Frontiers in …, 2022 - frontiersin.org
Objectives Systemic sclerosis (SSc) is an autoimmune disease caused by various
pathogenic factors, including hypoxia. Hypoxia stimulates the production of the extracellular …