Corneal nerves are responsible for the sensations of touch, pain, and temperature and play
an important role in the blink reflex, wound healing, and tear production and secretion …

The initial reinforcing properties of drugs of abuse, such as cocaine, are largely attributed to
their ability to activate the mesolimbic dopamine system. Resulting increases in extracellular …

Drug development consumes huge amounts of time and money and the search for novel
analgesics, which are urgently required, is particularly difficult, having resulted in many …

The widespread use of levofloxacin (LEV) and oxytetracycline (OTC) in hospitals and farms
inevitably contributes to water pollution through waste disposal processes, municipal …

Minocycline strongly inhibits microglial activation, which contributes to central sensitization,
a major mechanism underlying chronic pain development. We hypothesized that the …

The recent outbreak of coronavirus disease 2019 (COVID-19) has gained considerable
attention worldwide due to its increased potential to spread and infect the general …

Background Physicians have long reported that patients with chronic pain show higher
tendencies for alcohol use disorder (AUD), and AUD patients appear to have higher pain …

High-yielding industrial Streptomyces producer is usually obtained by multiple rounds of
random mutagenesis and screening. These strains have great potential to be developed as …

Central poststroke pain (CPSP) is one of the neuropathic pain syndromes that can occur
following stroke involving the somatosensory system. However, the underlying mechanism …

Minocycline is a broad-spectrum tetracycline antibiotic with multiple actions, including anti-
inflammatory and neuroprotective effects, that was proposed as novel treatment for several …