Son of Sevenless (SOS) is a guanine nucleotide exchange factor that activates the important
cell signaling switch KRAS. SOS acts as a pacemaker for KRAS, the beating heart of cancer …

Non‑small cell lung cancer (NSCLC) is a malignant tumor with a high morbidity and mortality
rate that is a threat to human health. With the development of molecular targeted research …

Personalized medicine (PM) or precision medicine in oncology is an emerging approach for
tumor treatment and prevention that takes into account inter-and intra-tumor variability in …

The treatment of metastatic non-small cell lung cancer (NSCLC) has undergone a paradigm
shift over the last decade. Better molecular characterization of the disease has led to the …

Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare and highly aggressive
type of lung cancer, with a complex biology that shares similarities with both small-cell lung …

Simple Summary Persistent activation of STAT3 is frequently observed in non-small cell lung
cancer and is associated with a poor prognosis. Given the multifaceted role of STAT3 …

Kristen rat sarcoma (KRAS) is one of the most common oncogenes in human cancers. As a
guanine nucleotide exchange factor, Son of Sevenless Homologue 1 (SOS1) represents a …

Large-cell neuroendocrine carcinomas of the lung (LCNECs) are rare tumors representing 1–
3% of all primary lung cancers. Patients with LCNEC are predominantly male, older, and …

KRAS is the most commonly mutated oncogene. Targeted therapies have been developed
against mediators of key downstream signaling pathways, predominantly components of the …

Small cell lung cancer (SCLC) has limited therapeutic options and an exceptionally poor
prognosis. Understanding the oncogenic drivers of SCLC may help define novel therapeutic …