Programmed cell death (PCD) is an essential part of organismal development and plays
fundamental roles in host defense against pathogens and the maintenance of homeostasis …

Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …

Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …

Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …

Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …

Pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance and
immunotherapeutic resistance. We discovered upregulation of receptor-interacting …

Summary Interferon-gamma (IFN-γ) has pleiotropic effects on cancer immune checkpoint
blockade (ICB), including roles in ICB resistance. We analyzed gene expression in ICB …

Cis-diamminedichloridoplatinum (II)(cisplatin) is a chemotherapeutic drug currently
prescribed for the treatment of many types of human cancer, but its use is associated with …

Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition
to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and …

Alzheimer's disease (AD) is characterized by a specific pattern of neuropathological
changes, including extracellular amyloid β (Aβ) deposits, intracellular neurofibrillary tangles …