Programming inflammatory cell death for therapy
S Christgen, RE Tweedell, TD Kanneganti - Pharmacology & therapeutics, 2022 - Elsevier
Programmed cell death (PCD) is an essential part of organismal development and plays
fundamental roles in host defense against pathogens and the maintenance of homeostasis …
fundamental roles in host defense against pathogens and the maintenance of homeostasis …
The molecular machinery of regulated cell death
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a
biologically uncontrolled process, whereas RCD involves tightly structured signaling …
biologically uncontrolled process, whereas RCD involves tightly structured signaling …
The double-edged functions of necroptosis
K Ye, Z Chen, Y Xu - Cell Death & Disease, 2023 - nature.com
Necroptosis refers to a regulated form of cell death induced by a variety of stimuli. Although it
has been implicated in the pathogenesis of many diseases, there is evidence to support that …
has been implicated in the pathogenesis of many diseases, there is evidence to support that …
[HTML][HTML] Cisplatin-induced ototoxicity: From signaling network to therapeutic targets
X Wang, Y Zhou, D Wang, Y Wang, Z Zhou… - Biomedicine & …, 2023 - Elsevier
Administration of cisplatin, a common chemotherapeutic drug, has an inevitable side effect
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …
of sensorineural hearing loss. The main etiologies are stria vascularis injury, spiral ganglion …
Necroptosis in immuno-oncology and cancer immunotherapy
J Sprooten, P De Wijngaert, I Vanmeerbeek, S Martin… - Cells, 2020 - mdpi.com
Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …
subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain …
RIP1 kinase drives macrophage-mediated adaptive immune tolerance in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance and
immunotherapeutic resistance. We discovered upregulation of receptor-interacting …
immunotherapeutic resistance. We discovered upregulation of receptor-interacting …
The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
L Cucolo, Q Chen, J Qiu, Y Yu, M Klapholz… - Immunity, 2022 - cell.com
Summary Interferon-gamma (IFN-γ) has pleiotropic effects on cancer immune checkpoint
blockade (ICB), including roles in ICB resistance. We analyzed gene expression in ICB …
blockade (ICB), including roles in ICB resistance. We analyzed gene expression in ICB …
Cisplatin-induced ototoxicity: updates on molecular targets
E Gentilin, E Simoni, M Candito, D Cazzador… - Trends in molecular …, 2019 - cell.com
Cis-diamminedichloridoplatinum (II)(cisplatin) is a chemotherapeutic drug currently
prescribed for the treatment of many types of human cancer, but its use is associated with …
prescribed for the treatment of many types of human cancer, but its use is associated with …
Molecular insights into the mechanism of necroptosis: the necrosome as a potential therapeutic target
J Chen, R Kos, J Garssen, F Redegeld - Cells, 2019 - mdpi.com
Necroptosis, or regulated necrosis, is an important type of programmed cell death in addition
to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and …
to apoptosis. Necroptosis induction leads to cell membrane disruption, inflammation and …
Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer's disease
MJ Koper, E Van Schoor, S Ospitalieri… - Acta …, 2020 - Springer
Alzheimer's disease (AD) is characterized by a specific pattern of neuropathological
changes, including extracellular amyloid β (Aβ) deposits, intracellular neurofibrillary tangles …
changes, including extracellular amyloid β (Aβ) deposits, intracellular neurofibrillary tangles …