Lipid peroxidation-induced DNA damage in cancer-prone inflammatory diseases: a review of published adduct types and levels in humans
U Nair, H Bartsch, J Nair - Free Radical Biology and Medicine, 2007 - Elsevier
Persistent oxidative stress and excess lipid peroxidation (LPO), induced by inflammatory
processes, impaired metal storage, and/or dietary imbalance, cause accumulations and …
processes, impaired metal storage, and/or dietary imbalance, cause accumulations and …
[HTML][HTML] DNA adducts with lipid peroxidation products
IA Blair - Journal of Biological Chemistry, 2008 - ASBMB
Homolytic decomposition of PUFA2-derived lipid hydroperoxides results in formation of the
α, ß-unsaturated aldehydic bifunctional electrophiles DDE, EDE, HNE, HPNE, MDA (shown …
α, ß-unsaturated aldehydic bifunctional electrophiles DDE, EDE, HNE, HPNE, MDA (shown …
DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice
G Gamboa da Costa, MI Churchwell… - Chemical research in …, 2003 - ACS Publications
Acrylamide (AA) is a high production volume chemical with many industrial uses; however,
recent findings of ppm levels in starchy foods cooked at high temperature have refocused …
recent findings of ppm levels in starchy foods cooked at high temperature have refocused …
Liquid chromatography-electrospray ionization-mass spectrometry: the future of DNA adduct detection
R Singh, PB Farmer - Carcinogenesis, 2006 - academic.oup.com
Over the past 40 years considerable emphasis has been placed on the development of
accurate and sensitive methods for the detection and quantitation of DNA adducts. The …
accurate and sensitive methods for the detection and quantitation of DNA adducts. The …
[HTML][HTML] Genotoxic and epigenotoxic effects in mice exposed to concentrated ambient fine particulate matter (PM2.5) from São Paulo city, Brazil
AAF de Oliveira, TF de Oliveira, MF Dias… - Particle and fibre …, 2018 - Springer
Abstract Background The Metropolitan Area of São Paulo has a unique composition of
atmospheric pollutants, and positive correlations between exposure and the risk of diseases …
atmospheric pollutants, and positive correlations between exposure and the risk of diseases …
Development of the adductome approach to detect DNA damage in humans
RA Kanaly, T Hanaoka, H Sugimura… - Antioxidants & redox …, 2006 - liebertpub.com
The development of new strategies designed to detect DNA damage caused by oxidative
stress and other means may advance our understanding of the roles of such types of …
stress and other means may advance our understanding of the roles of such types of …
Screening for DNA adducts by data-dependent constant neutral loss-triple stage mass spectrometry with a linear quadrupole ion trap mass spectrometer
EE Bessette, AK Goodenough, S Langouët… - Analytical …, 2009 - ACS Publications
A two-dimensional linear quadrupole ion trap mass spectrometer (LIT/MS) was employed to
simultaneously screen for DNA adducts of environmental, dietary, and endogenous …
simultaneously screen for DNA adducts of environmental, dietary, and endogenous …
Biological relevance of adduct detection to the chemoprevention of cancer
RA Sharma, PB Farmer - Clinical Cancer Research, 2004 - AACR
Adducts arise from the chemical modification of bases in DNA or amino acids in proteins by
toxic chemicals. Many chemicals known to be carcinogenic in humans have been shown to …
toxic chemicals. Many chemicals known to be carcinogenic in humans have been shown to …
DNA adducts: mass spectrometry methods and future prospects
Detection of DNA adducts is widely used for the monitoring of exposure to genotoxic
carcinogens. Knowledge of the nature and amounts of DNA adducts formed in vivo also …
carcinogens. Knowledge of the nature and amounts of DNA adducts formed in vivo also …
Quantitative analysis of the oxidative DNA lesion, 2,2-diamino-4-(2-deoxy-β-d-erythro-pentofuranosyl)amino]-5(2H)-oxazolone (oxazolone), in vitro and in vivo by …
B Matter, D Malejka-Giganti, AS Csallany… - Nucleic acids …, 2006 - academic.oup.com
ABSTRACT A major DNA oxidation product, 2, 2-diamino-4-[(2-deoxy-β-d-erythro-
pentofuranosyl) amino]-5 (2 H)-oxazolone (oxazolone), can be generated either directly by …
pentofuranosyl) amino]-5 (2 H)-oxazolone (oxazolone), can be generated either directly by …