Persistent oxidative stress and excess lipid peroxidation (LPO), induced by inflammatory
processes, impaired metal storage, and/or dietary imbalance, cause accumulations and …

Homolytic decomposition of PUFA2-derived lipid hydroperoxides results in formation of the
α, ß-unsaturated aldehydic bifunctional electrophiles DDE, EDE, HNE, HPNE, MDA (shown …

Acrylamide (AA) is a high production volume chemical with many industrial uses; however,
recent findings of ppm levels in starchy foods cooked at high temperature have refocused …

Over the past 40 years considerable emphasis has been placed on the development of
accurate and sensitive methods for the detection and quantitation of DNA adducts. The …

Abstract Background The Metropolitan Area of São Paulo has a unique composition of
atmospheric pollutants, and positive correlations between exposure and the risk of diseases …

The development of new strategies designed to detect DNA damage caused by oxidative
stress and other means may advance our understanding of the roles of such types of …

A two-dimensional linear quadrupole ion trap mass spectrometer (LIT/MS) was employed to
simultaneously screen for DNA adducts of environmental, dietary, and endogenous …

Adducts arise from the chemical modification of bases in DNA or amino acids in proteins by
toxic chemicals. Many chemicals known to be carcinogenic in humans have been shown to …

Detection of DNA adducts is widely used for the monitoring of exposure to genotoxic
carcinogens. Knowledge of the nature and amounts of DNA adducts formed in vivo also …

ABSTRACT A major DNA oxidation product, 2, 2-diamino-4-[(2-deoxy-β-d-erythro-
pentofuranosyl) amino]-5 (2 H)-oxazolone (oxazolone), can be generated either directly by …