[图书][B] Human behavior in the social environment: Perspectives on development, the life course, and macro contexts

A Rogers - 2020 - taylorfrancis.com
In this new aggregated edition of Anissa Taun Roger's Human Behavior in the Social
Environment, readers will find a comprehensive overview of the issues related to human …

[HTML][HTML] Mutations and Modeling of the Chromatin Remodeler CHD8 Define an Emerging Autism Etiology

RA Barnard, MB Pomaville, BJ O'roak - Frontiers in neuroscience, 2015 - frontiersin.org
Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder with a strong
but complex genetic component. Recent family based exome-sequencing strategies have …

[HTML][HTML] Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia

ND Merner, MR Chandler, C Bourassa… - Frontiers in cellular …, 2015 - frontiersin.org
Many encoded gene products responsible for neurodevelopmental disorders (NDs) like
autism spectrum disorders (ASD), schizophrenia (SCZ), intellectual disability (ID), and …

[HTML][HTML] MicroRNA profiling of neurons generated using induced pluripotent stem cells derived from patients with schizophrenia and schizoaffective disorder, and …

D Zhao, M Lin, J Chen, E Pedrosa, A Hrabovsky… - PloS one, 2015 - journals.plos.org
We are using induced pluripotent stem cell (iPSC) technology to study neuropsychiatric
disorders associated with 22q11. 2 microdeletions (del), the most common known …

[HTML][HTML] Full-length isoform transcriptome of the developing human brain provides further insights into autism

KK Chau, P Zhang, J Urresti, M Amar, AB Pramod… - Cell reports, 2021 - cell.com
Alternative splicing plays an important role in brain development, but its global contribution
to human neurodevelopmental diseases (NDDs) requires further investigation. Here we …

Schizophrenia: susceptibility genes, dendritic-spine pathology and gray matter loss

MR Bennett - Progress in neurobiology, 2011 - Elsevier
Gray matter loss in the cortex is extensive in schizophrenia, especially in the prefrontal-
temporal-network (PTN). Several molecules such as neuregulin-1 (NRG1) and its ErbB4 …

The role of genetics and genomics in clinical psychiatry

MR Hoehe, DJ Morris-Rosendahl - Dialogues in clinical …, 2018 - Taylor & Francis
The enormous successes in the genetics and genomics of many diseases have provided the
basis for the advancement of precision medicine. Thus, the detection of genetic variants …

[HTML][HTML] Paternal-age-related de novo mutations and risk for five disorders

JL Taylor, JCPG Debost, SU Morton, EM Wigdor… - Nature …, 2019 - nature.com
There are established associations between advanced paternal age and offspring risk for
psychiatric and developmental disorders. These are commonly attributed to genetic …

[HTML][HTML] Pathogenetic model for Tourette syndrome delineates overlap with related neurodevelopmental disorders including Autism

RA Clarke, S Lee, V Eapen - Translational psychiatry, 2012 - nature.com
Tourette syndrome (TS) is a highly heritable neuropsychiatric disorder characterised by
motor and vocal tics. Despite decades of research, the aetiology of TS has remained elusive …

[HTML][HTML] Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia

GW Crabtree, JA Gogos - Frontiers in synaptic neuroscience, 2014 - frontiersin.org
Synaptic plasticity alters the strength of information flow between presynaptic and
postsynaptic neurons and thus modifies the likelihood that action potentials in a presynaptic …