Transcription factor LSF is essential for cell cycle progression, being required for activating
expression of the thymidylate synthase (Tyms) gene at the G1/S transition. We previously …

purpose. Poly (ADP-ribose) polymerase (PARP)-1 is a nuclear enzyme essential in several
cellular functions such as DNA repair, DNA transcription, carcinogenesis, and apoptosis …

KRAS mutations are known to be the most recurrent gain-of-function changes instigated in
patients with cancer. The RAS gene family is often mutated in most of the human cancers …

The ERK/MAPK signalling cascade is involved in many cellular functions. In mice, the
targeted ablation of genes coding for members of this pathway is often associated with …

Hepatocellular carcinoma (HCC) is the sixth most common cancer worldwide and the
second leading cause of cancer mortality. Despite the prevalence of HCC, there is only one …

Objectives: The presence of the endometrium outside the uterine cavity affects about 10% of
women of childbearing age. Studies of the progression of endometriosis to cancer have …

Objectives Proliferation of hepatocytes in vitro can be stimulated by growth factors such as
epidermal growth factor (EGF), but the role of vasoactive intestinal peptide (VIP) remains …

Abstract Factor Quinolinone Inhibitor 1 (FQI1), discovered as a small molecule inhibitor of
the transcription factor LSF, causes cell death in many cancer cell lines and inhibits tumor …

Abstract Factor Quinolinone Inhibitor 1 (FQI1) is a novel anti-cancer compound, having
shown efficacy against hepatocellular carcinoma (HCC) in multiple murine tumor models …

Mammalian Tfcp2l1 and Tfcp2 are grouped into the CP2 subfamily of the grainyhead/CP2
(Grh/CP2) transcription factors involved in pluripotency maintenance and self-renewal of …