[HTML][HTML] Astrocytes: integrators of arousal state and sensory context
The integration of external information with the internal state of the body is central to the
survival of virtually every multicellular organism. However, a complete picture of the …
survival of virtually every multicellular organism. However, a complete picture of the …
[HTML][HTML] Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?
Life stressors can wreak havoc on our health, contributing to mood disorders like major
depressive disorder (MDD), a widespread and debilitating condition. Unfortunately, current …
depressive disorder (MDD), a widespread and debilitating condition. Unfortunately, current …
[HTML][HTML] Dysfunctional serotonergic neuron-astrocyte signaling in depressive-like states
C González-Arias, A Sánchez-Ruiz, J Esparza… - Molecular …, 2023 - nature.com
Astrocytes play crucial roles in brain homeostasis and are regulatory elements of neuronal
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …
and synaptic physiology. Astrocytic alterations have been found in Major Depressive …
Astrocytes in Post-Stroke Depression: Roles in Inflammation, Neurotransmission, and Neurotrophin Signaling
D Jing, X Hou, X Guo, X Zhao, K Zhang… - Cellular and Molecular …, 2023 - Springer
Post-stroke depression (PSD) is a frequent and disabling complication of stroke that affects
up to one-third of stroke survivors. The pathophysiology of PSD involves multiple …
up to one-third of stroke survivors. The pathophysiology of PSD involves multiple …
Age-atypical brain functional networks in autism spectrum disorder: a normative modeling approach
A Jiang, X Ma, S Li, L Wang, B Yang, S Wang… - Psychological …, 2024 - cambridge.org
BackgroundDespite extensive research into the neural basis of autism spectrum disorder
(ASD), the presence of substantial biological and clinical heterogeneity among diagnosed …
(ASD), the presence of substantial biological and clinical heterogeneity among diagnosed …
[HTML][HTML] Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice
MY Yin, L Guo, LJ Zhao, C Zhang, WP Liu, CY Zhang… - BMC medicine, 2023 - Springer
Background Genome-wide association studies (GWAS) have reported single-nucleotide
polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome …
polymorphisms (SNPs) in the VRK serine/threonine kinase 2 gene (VRK2) showing genome …
Astrocyte-specific inhibition of sigma-1 receptor leads to depressive-like behaviors in mice via activation of NF-κB-induced neuroinflammation
JY Wang, P Ren, LY Cui, JY Duan, HL Chen… - Brain, Behavior, and …, 2024 - Elsevier
Major depressive disorder (MDD) is a global health burden characterized by persistent low
mood, deprivation of pleasure, recurrent thoughts of death, and physical and cognitive …
mood, deprivation of pleasure, recurrent thoughts of death, and physical and cognitive …
The neurobiological mechanisms and therapeutic prospect of extracellular ATP in depression
K Wang, S Huang, D Fu, X Yang, L Ma… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Depression is a prevalent psychiatric disorder with high long‐term morbidities,
recurrences, and mortalities. Despite extensive research efforts spanning decades, the …
recurrences, and mortalities. Despite extensive research efforts spanning decades, the …
Modularity-Constrained Dynamic Representation Learning for Interpretable Brain Disorder Analysis with Functional MRI
Resting-state functional MRI (rs-fMRI) is increasingly used to detect altered functional
connectivity patterns caused by brain disorders, thereby facilitating objective quantification …
connectivity patterns caused by brain disorders, thereby facilitating objective quantification …
Knocking out Selenium Binding Protein 1 Induces Depressive-Like Behavior in Mice
Y Jia, X Zhang, Y Wang, Y Liu, J Dai, L Zhang… - … Trace Element Research, 2024 - Springer
Abstract Selenium binding protein 1 (SELENBP1) is involved in neurologic disorders, such
as multiple sclerosis, spinal cord injury, Parkinson's disease, epilepsy, and schizophrenia …
as multiple sclerosis, spinal cord injury, Parkinson's disease, epilepsy, and schizophrenia …