The marine environment is a huge reservoir of biodiversity and represents an excellent
source of chemical compounds, some of which have large economical values. In the urgent …

Highlights•Metabolomics and systems biology at large can accelerate lead compound
discovery from natural sources.•Systems-level interpretation of omics data aids in the …

Bacterial natural products have found many important industrial applications. Yet traditional
discovery pipelines often prioritize individual natural product families despite the presence …

Conspectus Analytical methods allow for the structure determination of submilligram
quantities of complex secondary metabolites. This has been driven in large part by …

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a
structurally diverse group of natural products. They feature a wide range of intriguing post …

A continued rise of antibiotic resistance and shortages of effective antibiotics necessitate the
discovery and development of new antibiotics with novel modes of action (MoAs) against …

Covering: 2017.01 to 2023.11 Natural products biosynthesized by myxobacteria are
appealing due to their sophisticated chemical skeletons, remarkable biological activities …

Microbial natural products and their structural analogues have widely used as
pharmaceutical agents, especially for infectious diseases and cancer. Despite this success …

Natural product (NP)-based antibiotics have been exploited for more than eighty years and
continue saving uncountable lives every year. However, antimicrobial R&D is inadequate to …

Microbial natural products (NPs) and their derivates have been widely used in health care
and agriculture during the past few decades. Although large-scale bacterial or fungal (meta) …