Frontotemporal lobar degeneration

M Grossman, WW Seeley, AL Boxer, AE Hillis… - Nature Reviews …, 2023 - nature.com
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset
dementia and presents with early social–emotional–behavioural and/or language changes …

Neurofilament light chain as biomarker for amyotrophic lateral sclerosis and frontotemporal dementia

F Verde, M Otto, V Silani - Frontiers in neuroscience, 2021 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related
currently incurable neurodegenerative diseases. ALS is characterized by degeneration of …

Comprehensive cross-sectional and longitudinal analyses of plasma neurofilament light across FTD spectrum disorders

TF Gendron, MG Heckman, LJ White, AM Veire… - Cell Reports …, 2022 - cell.com
Frontotemporal dementia (FTD) therapy development is hamstrung by a lack of
susceptibility, diagnostic, and prognostic biomarkers. Blood neurofilament light (NfL) shows …

[HTML][HTML] Neuroimaging in frontotemporal dementia: heterogeneity and relationships with underlying neuropathology

BT Peet, S Spina, N Mundada, R La Joie - Neurotherapeutics, 2021 - Elsevier
Frontotemporal dementia encompasses a group of clinical syndromes defined
pathologically by degeneration of the frontal and temporal lobes. Historically, these …

Advances and controversies in frontotemporal dementia: diagnosis, biomarkers, and therapeutic considerations

BF Boeve, AL Boxer, F Kumfor, Y Pijnenburg… - The Lancet …, 2022 - thelancet.com
Frontotemporal dementia comprises a group of clinical syndromes that are characterised by
progressive changes in behaviour, executive function, or language. The term frontotemporal …

Biomarker discovery and development for frontotemporal dementia and amyotrophic lateral sclerosis

JS Katzeff, F Bright, K Phan, JJ Kril, LM Ittner… - Brain, 2022 - academic.oup.com
Frontotemporal dementia refers to a group of neurodegenerative disorders characterized by
behaviour and language alterations and focal brain atrophy. Amyotrophic lateral sclerosis is …

Advances in treatment of frontotemporal dementia

N Magrath Guimet… - The Journal of …, 2022 - Am Neuropsych Assoc
In this review, the authors explored the clinical features of frontotemporal dementia (FTD),
focusing on treatment. The clinical features of FTD are unique, with disinhibition, apathy …

A data-driven disease progression model of fluid biomarkers in genetic frontotemporal dementia

EL Van Der Ende, EE Bron, JM Poos, LC Jiskoot… - Brain, 2022 - academic.oup.com
Several CSF and blood biomarkers for genetic frontotemporal dementia have been
proposed, including those reflecting neuroaxonal loss (neurofilament light chain and …

From recognition to remedy: The significance of biomarkers in neurodegenerative disease pathology

C Toader, N Dobrin, FM Brehar, C Popa… - International journal of …, 2023 - mdpi.com
With the inexorable aging of the global populace, neurodegenerative diseases (NDs) like
Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) …

Distinguishing frontotemporal lobar degeneration tau from TDP-43 using plasma biomarkers

KAQ Cousins, LM Shaw, A Chen-Plotkin… - JAMA …, 2022 - jamanetwork.com
Importance Biomarkers are lacking that can discriminate frontotemporal lobar degeneration
(FTLD) associated with tau (FTLD-tau) or TDP-43 (FTLD-TDP). Objective To test whether …