The current opioid epidemic is one of the most severe public health crisis in US history.
Responding to it has been difficult due to its rapidly changing nature and the severity of its …

Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …

Background: Emotional disorders are common comorbid affectations that exacerbate the
severity and persistence of chronic pain. Specifically, depressive symptoms can lead to an …

Aversive motivation plays a prominent role in driving individuals to exert cognitive control.
However, the complexity of behavioral responses attributed to aversive incentives creates …

Anhedonia is an elusive symptom in depression symptomatology. The present review
frames the notion of anhedonia as reduced ability to experience pleasure and diminished …

Emerging preclinical and clinical evidence indicate that the lateral habenula plays a major
role in the pathophysiology of depressive illness. Aberrant increases in neuronal activity in …

The habenula (Hb) is a phylogenetically old epithalamic structure differentiated into two
nuclear complexes, the medial (MHb) and lateral habenula (LHb). After decades of search …

Independent from homeostatic needs, the consumption of foods originating from
hyperpalatable diets is defined as hedonic eating. Hedonic eating can be observed in many …

Synaptic vesicle release is regulated by upwards of 30 proteins at the fusion complex alone,
but disruptions in any one of these components can have devastating consequences for …

Anxiety disorders often co-occur with alcohol use disorders, but the mechanisms underlying
this comorbidity remain elusive. Previously, we reported that rats withdrawn from chronic …